Hyponatremia is the most common electrolyte disorder. Thiazides, antidepressants, antipsychotic drugs, and antiepileptic drugs are well-known causes of hyponatremia. Proton pump inhibitor use is a rare cause o...
Mon Jun 29, 2020 03:00
The coronavirus disease 2019 (Covid-19) pandemic has caused catastrophic disease worldwide, although children have been relatively spared. Severe lung involvement with acute respiratory failure is the most common complication of Covid-19 in adults, but many have complications in multiple organs,…
Mon Jun 29, 2020 03:00
We present a complete protocol for postmortem diagnosis of animal rabies under field conditions using a rapid immunochromatographic diagnostic test (RIDT), from brain biopsy sampling to final interpretation. We also describe further applications using the device for molecular analysis and viral genotyping.
Mon Jun 29, 2020 20:53
Publication date: Available online 29 June 2020Source: Journal of Cranio-Maxillofacial SurgeryAuthor(s): Torsten Schlosshauer, Lara Kueenzlen, Shafreena Kuehn, Robert Sader, Ulrich Rieger
Mon Jun 29, 2020 20:20
Publication date: Available online 28 June 2020Source: Annals of Diagnostic PathologyAuthor(s): Alberto M. Marchevsky, Ann E. Walts, Birgit I. Lissenberg-Witte, Erik Thunnissen
Mon Jun 29, 2020 20:19
Abstract As the recent update of General anaesthesia compared to spinal anaesthesia (GAS) studies has been published in 2019, together with other clinical evidence, the human studies provided an overwhelming mixed evidence of an association between anaesthesia exposure in early childhood and later neurodevelopment changes in children. Pre-clinical studies in animals provided strong evidence on how anaesthetic and sedative agents (ASAs) causing neurotoxicity in developing brain...
Mon Jun 29, 2020 03:00
Publication date: Available online 29 June 2020Source: Magnetic Resonance ImagingAuthor(s): Yan Wu, Yajun Ma, Jiang Du, Lei Xing
Mon Jun 29, 2020 19:27
Abstract Purpose Thyroid hormone receptors (THR) have manifold functions and are involved in the carcinogenesis of several tumor types. Within this study, we aimed to investigate the expression pattern (nuclear versus cytoplasmic) of the THR alpha and its impact on patients survival in ovarian cancer (OvCa). Methods The presence...
Mon Jun 29, 2020 19:16
Abstract Purpose Currently, the routine screening program has insufficient capacity for the early diagnosis of lung cancer. Therefore, a type of chitosan-molecular beacon (CS-MB) probe was developed to recognize the miR-155-5p and image the lung cancer cells for the early diagnosis. Methods Based on the molecular beacon (MB) technology...
Mon Jun 29, 2020 19:16
Abstract Dr. Tarek Haykal et al. (145:1795–1809, 2019) reported a meta-analysis of aspirin for the primary prevention of cancer in individuals without known cancer. The authors found that aspirin use was not associated with significant reduction in cancer mortality or incidence, but with higher rates of bleeding. The findings of this study added some evidence to the clinical practice. However, several issues might have compromised the strength of the evidence of this systematic...
Mon Jun 29, 2020 19:16
Abstract Objective Prostate cancer (PCa) is an aggressive tumor. SHC SH2-domain-binding protein 1 (SHCBP1) has been identified frequently upregulated in various cancers, in addition to PCa. The aims of this study were to determine the relationships between SHCBP1 and clinicopathological characteristics of PCa and to explore the role of SHCBP1 in PCa proliferation and progression. ...
Mon Jun 29, 2020 19:16
Abstract Purpose In breast cancer (BC), the duration of endocrine adjuvant therapies (AT) has been extended continuously up to 10 years. We present an alternative explanation for the effect, which could enable shorter treatments. Method The relevant literature on chemoprevention and (neo-)adjuvant therapy was reviewed. Data for initiation...
Mon Jun 29, 2020 19:16
Abstract Purpose With the increasing interest in treatment decision-making based on risk prediction models, it is essential for clinicians to understand the steps in developing and interpreting such models. Methods A retrospective registry of 20 Dutch hospitals with data on patients treated for castration-resistant prostate cancer was...
Mon Jun 29, 2020 19:16
Abstract Purpose Melatonin is an amphipathic indolamine molecule ubiquitously present in all organisms ranging from cyanobacteria to humans. The pineal gland is the site of melatonin synthesis and secretion under the influence of the retinohypothalamic tract. Some extrapineal tissues (skin, lens, gastrointestinal tract, testis, ovary, lymphocytes, and astrocytes) also enable to produce melatonin. Physiologically, melatonin regulates...
Mon Jun 29, 2020 19:16
Abstract Purpose Breast cancer is the leading cause of cancer death in females. Histone modifications have been shown to have an influence on the gene expression. This study focusses on the histone modifications H3K9ac and H3K4me3 in breast cancer and their impact on survival Methods H3K4me3 and H3K9ac expression was immunohistochemically...
Mon Jun 29, 2020 19:16
Abstract Purpose To investigate the correlation between number of retrieved lymph nodes (rLNs) and prognosis and further ascertain the optimal number of rLNs with a beneficial survival impact in patients with pN0 colon cancer. Methods The Surveillance, Epidemiology, and End Results (SEER) database was searched for pN0 colon cancer cases....
Mon Jun 29, 2020 19:16
In the original article published, the first author’s affiliation is incorrect.
Mon Jun 29, 2020 19:16
Abstract Introduction Immune checkpoint inhibitors (ICIs) are approved in multiple indications for cancer care. Most of the clinical trials have not questioned shorter than until disease progression approaches. In this study, we present results from a cohort of multiple advanced cancers treated with restricted anti-PD-(L)1 therapy. Methods ...
Mon Jun 29, 2020 19:16
Abstract Objective To evaluate the patterns of vitamin and herbal supplement use among patients with advanced gastrointestinal (GI) cancers and the association of such behavior with the efficacy and toxicity of systemic anticancer treatment. Methods Project data sphere (PDS) was used to access de-identified datasets of eight clinical...
Mon Jun 29, 2020 19:16
Abstract Purpose Esophageal cancer (EC) is one of the most lethal gastrointestinal malignancies. Immunotherapy is a promising treatment modality for this disease. However, broader implementation of EC immunotherapy has been discouraged because of insufficient understanding of tumor interactions with the immune system. As with other malignancies, the current research on EC focuses on deciphering the immune cell signatures within...
Mon Jun 29, 2020 19:16
Abstract Purpose Although biomarkers for patients with metastatic colorectal cancer exist, the benefit patients with RAS mutated tumors derive from established regimens is unclear. Methods Efficacy of therapeutic strategies available for RAS mutated patients (addition of chemotherapeutic agents and/or anti angiogenic agents) were investigated...
Mon Jun 29, 2020 19:16
Abstract Purpose Although adoptive cell therapy with chimeric antigen receptor (CAR)-engineered T cells has shown durable clinical efficacy in patients with CD19+ B cell malignancies, the application of this approach to solid tumors is challenging. The goal of this proof-of-concept study was to investigate whether loading of CD19-CAR T cells (CART19) with anti-HER2 or anti-EGFR bispecific antibodies (BiAb) will target HER2+/EGFR+...
Mon Jun 29, 2020 19:16
Abstract Purpose To explore whether targeted next generation sequencing (NGS) of liquid biopsy in advanced non-small cell lung cancer (NSCLC) could potentially overcome the innate problems that arise with standard tissue biopsy, like intratumoral heterogeneity and the inability to obtain adequate samples for analysis. Methods The Scopus,...
Mon Jun 29, 2020 19:16
Abstract Purpose Interleukin-10 (IL-10) is an immunoregulatory cytokine and its cervical and serum concentrations have been associated with a poor prognosis of cervical cancer. The rs1800872 polymorphism (c.-592C>A) in the promotor region of the IL-10 gene affects the production and expression of IL-10 and thus is able to determine the immune response profile in the cervix. Therefore, the aim of this work is to state the association...
Mon Jun 29, 2020 19:16
Abstract Background Numerous studies have reported the preventive and protective effects of aspirin in patients with rectal cancer. However, it is not clear whether aspirin can be used as an assistance drug in preoperative neoadjuvant chemoradiotherapy. Therefore, this study will explore the efficacy of aspirin as an adjuvant agent in rectal cancer neoadjuvant chemoradiotherapy. ...
Mon Jun 29, 2020 19:16
Abstract Introduction After transurethral resection of a bladder tumor, patients frequently have a recurrence of the disease, thereby requiring adjuvant therapy. Purpose The study aimed to determine the prognostic value of expression levels of p53, Ki-67, and survivin, and to develop a new prognostic model for patients with non-muscle-invasive...
Mon Jun 29, 2020 19:16
Mon Jun 29, 2020 19:08
Abstract Purpose Water recreation is one of the most popular activities for both fitness and leisure. The dangers of water activities have mostly been examined in the context of drowning and general bodily injuries. Despite the existing research, little is known about adult maxillofacial injuries in these settings. Methods We accessed the National...
Mon Jun 29, 2020 03:00
Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): David Gordon
Mon Jun 29, 2020 18:47
Publication date: Available online 28 June 2020Source: International Journal of PsychophysiologyAuthor(s): Sara B. LoTemplio, Emily E. Scott, Amy S. McDonnell, Rachel J. Hopman, Spencer Castro, David McNay, Ty L. McKinney, Kevin Greenberg, Brennan R. Payne, David L. Strayer
Mon Jun 29, 2020 18:47
Publication date: September 2020Source: Acta Histochemica, Volume 122, Issue 6Author(s): Ivana Milardović, Marija Vitlov Uljević, Katarina Vukojević, Sandra Kostić, Natalija Filipović
Mon Jun 29, 2020 18:34
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00885K, PaperXiaodong Sun, Fanyong Yan, Yingxia Jiang, Hao Zhang, Zhonghui Sun, Ruijie Wang, Yali CuiNitro group with strong electron-withdrawing effect can powerfully influence the fluorescence of fluorophores. In this work, through adjusting the nitro group at HBT fluorophore to construct phenylhydrazone structure, two probes...The content of this RSS Feed (c) The Royal Society of Chemistry
Mon Jun 29, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00770F, PaperTakahiro Hiono, Atsushi KunoGlycans attached to the viruses regulate their pathogenicity, immunogenicity, and antigenicity. We have previously demonstrated that lectin microarray provided an easy and highly sensitive platform for analyzing glycan profiles of...The content of this RSS Feed (c) The Royal Society of Chemistry
Mon Jun 29, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00720J, PaperDelphine Zanella, Monique Henket, Florence Schleich, Thibaut Dejong, Renaud Louis, Jean-François Focant, Pierre-Hugues StefanutoExhaled breath analysis has a high potential for early non-invasive diagnosis of lung inflammatory diseases, such as asthma. The characterization and understanding of the inflammatory metabolic pathways involved into volatile...The content of this RSS Feed (c) The Royal Society of Chemistry
Mon Jun 29, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00918K, PaperLeo Lebanov, Elisabet Fuguet, Javier Mauricio Melo, Marti RosesThis work provides the pKa at the biorelevant temperature of 37 ºC for a set of compounds proposed as internal standards for the internal standard capillary electrophoresis (IS-CE) method. This...The content of this RSS Feed (c) The Royal Society of Chemistry
Mon Jun 29, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00335B, PaperTatsumi Mizuta, Shu Takai, Toshiki Nishihata, Kenji Sueyoshi, Tatsuro Endo, Hideaki HisamotoHerein, a fully lipophilic ionic liquid (IL) comprising a lipophilic fluorescein anion and a trihexyltetradecylphosphonium cation was synthesized and used as the plasticizer for a plasticized poly(vinyl chloride) (PVC) membrane...The content of this RSS Feed (c) The Royal Society of Chemistry
Mon Jun 29, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00944J, PaperYi-Kun Li, Xiao-Yan Wang, Xun Liu, Ting Yang, Ming-Li Chen, Jian-Hua WangMetal-organic frameworks functionalized with Cd(Ⅱ) binding phage were for the first time fabricated for the isolation and preconcentration of ultra-trace cadmium. Highly specific Cd(Ⅱ) binding phages were screened through biological...The content of this RSS Feed (c) The Royal Society of Chemistry
Mon Jun 29, 2020 02:00
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