The paper invites to reappraise the role of psychosurgery for and within the development of functional stereotactic neurosurgery. It highlights the significant and long-lived role of stereotactic neurosurgery in the treatment of severe and chronic mental disorders. Stereotactic neurosurgery developed out of psychosurgery. It was leucotomy for psychiatric disorders and chronic pain that paved the way for stereotactic dorsomedial thalamotomy in these indications and subsequently for stereotactic surgery...
Mon Jun 29, 2020 08:55
Sun Jun 28, 2020 22:58
Abstract Neither the etiology nor a reliable treatment for palmoplantar pustulosis has been clearly established. Ozone nano‐bubble water, which is treated with nanosized ozone gas particles and has strong antimicrobial activity, has attracted attention as a future therapeutic option for palmoplantar pustulosis. Oral rinsing, particularly in the periodontal areas, with 10–20 mL ozone nano‐bubble water for a couple of minutes per night, was prescribed to 7 palmoplantar pustulosis patients, comprising...
Sun Jun 28, 2020 16:14
Abstract Aim Current quarantine conditions are a difficult process for individuals and can worsen the psychological state. Increased psychosocial stress can affect the course of many common “stress‐sensitive” skin conditions. This study examined the possible effects of COVID‐19 on hair and scalp diseases such as telogen effluvium (TE), alopecia areata (AA), and seborrheic dermatitis (SD) in individuals who had to stay at home for a long time and the patients’ methods of dealing with these diseases....
Sun Jun 28, 2020 15:53
Abstract Objective Mycosis fungoides (MF) is a chronic disease, causing serious morbidities and mortality. This study was designed to measure depression and anxiety levels in MF patients, and quality of life (QoL) assessments and to compare the results with controls. Methods Fifty‐two patients with a diagnosis of MF and 52 age and sex matching healthy controls were enrolled in this study. Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI) and the 36‐Item Short Form Health Survey...
Sun Jun 28, 2020 15:40
Abstract Cancer stem cells (CSC) are populations of cells responsible for tumor initiation, progression and therapeutic resistance in many cancers. In the present study, we aimed to investigate the expression pattern and clinical significance of the stem cell marker nestin, in Squaous cell carcinoma (SCC) and basal cell carcinoma (BCC). The samples (23 cases of BCC and 22 cases of SCC) were immunohistochemically examined for the expression of nestin and its correlation with the corresponding clinical...
Sun Jun 28, 2020 15:29
Abstract Background Primary focal hyperhidrosis is a common reason for dermatology outpatient visit and has significant impact on patient’s social and professional activities. The study describes the clinical profile of those patients and response with aluminum chloride hexahydrate lotion (ACH 20%) and oral glycopyrrolate (OGP). Methods A retrospective study was carried out at a tertiary care centre between the year 2016‐18. Details of history, baseline assessment, treatment response recorded...
Sun Jun 28, 2020 14:09
Abstract Angiokeratomas are benign vascular neoplasms that arise as solitary or multiple lesions, most commonly treated with excision, electrodessication, cryotherapy, or laser therapies. This case presents a young female whose solitary angiokeratoma was treated with topical 1% sirolimus cream, improving the appearance, symptoms and size of the lesion. Topical sirolimus cream may be a non‐ invasive treatment option for angiokeratomas with fewer risks than standard therapy that may be feasible and...
Sun Jun 28, 2020 14:05
Background Management of keloid is difficult, so there is always a need for adequate and effective therapy. Objectives In this study we explored and compared the efficacy and synergistic effect of combined intralesional radiofrequency (RF) and intralesional triamcinolone acetonide[TAC] with intralesional triamcinolone acetonide alone in the treatment of keloids. Methods Sixty patients with keloid were divided in two groups of 30 patients each. In both groups total 6 sittings every...
Sun Jun 28, 2020 14:03
Abstract There is a significant psychiatric comorbidity that exists in multiple dermatological conditions, stemming from the patient's own psychological make up. This article reviews personality disorders and their types, which influence the course and prognosis of several psychodermatological disorders. Self‐inflicted skin lesions, for example, are usually associated with obsessive‐compulsive behavior, but they also share connections to Narcissistic and Borderline personality disorders. Body dysmorphic...
Sun Jun 28, 2020 14:03
Sun Jun 28, 2020 14:00
SDRIFE(symmetrical drug related intertriginous and flexural exanthem) is a benign self limiting adverse drug reaction primarily affecting the intertriginous,gluteal and flexural regions symmetrically in the absence of systemic involvement.It is considered to be a variant of baboon syndrome.Pathogenesis is poorly understood but is thought to be result of a delayed hypersensitivity response after exposure to the drug.Commonly implicated drugs are beta‐lactam antibiotics. With the rising incidence of...
Sun Jun 28, 2020 13:54
Publication date: Available online 29 June 2020Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): Stanley Fineman, David A. Khan, Vivian Hernandez-Trujillo, Gerald B. Lee
Mon Jun 29, 2020 12:06
Summary Background and objectives The incidence of melanoma is rising and prevention plays an important role. Multiple nevi as well as a medical history of melanoma are important risk factors. In affected patients, a two‐step algorithm consisting of total‐body photography (TBP) and sequential digital dermatoscopy (SDD) is a helpful diagnostic tool. Patients and methods This was a retrospective observational study that lasted six years in order to evaluate the significance of the two‐step...
Mon Jun 29, 2020 11:52
Summary Background Surgical site infections (SSI), bleeding, and necrosis are possible complications of dermatological surgery, and their rates are well described for Mohs surgery (same‐day surgery). However, there are only limited data on their occurrence in microscopically controlled surgery of the form in which it is practiced in German hospitals (next‐day surgery). Materials and Methods We performed a retrospective analysis of patient records of patients hospitalized for microscopically...
Sun Jun 28, 2020 20:51
Ultramicropore control of molecular sieving in two forms of calcium trimesate leads to the first non‐membrane solid that serves as a molecular sieve for H2 over slightly larger gas molecules, including CO2 and N2. Abstract The high energy footprint of commodity gas purification and increasing demand for gases require new approaches to gas separation. Kinetic separation of gas mixtures through molecular sieving can enable separation by molecular size or shape exclusion. Physisorbents must...
Mon Jun 29, 2020 11:18
A supramolecular tweezer catalyst has been synthesized that is capable of oxidizing aliphatic ammonium salts at the deactivated methylene positions C3/C4. The catalyst is able to override the intrinsic reactivity in the C−H oxidation of these substrates. Abstract The site‐selective C−H oxidation of unactivated positions in aliphatic ammonium chains poses a tremendous synthetic challenge, for which a solution has not yet been found. Here, we report the preferential oxidation of the strongly...
Mon Jun 29, 2020 11:18
Perovskite solar cells (PSCs) are a promising photovoltaic technology for stretchable applications. A self‐healing polyurethane (s‐PU) is applied as a scaffold in perovskite films where it enhances crystallinity and passivates the grain boundary. The stretchable PSCs with s‐PU have a stable efficiency of 19.15 %. The s‐PU releases mechanical stress and repairs cracks at the grain boundary. Devices cycled 1000 times at 20 % stretch regained 88 % of their original efficiency. Abstract Perovskite...
Mon Jun 29, 2020 11:18
Lucky seven : The challenging C7−H activation of indoles has been accomplished by ruthenium(II) catalysis. The versatile ruthenium catalysis allowed C−N and C−C bond formation, scalable reactions, and the traceless removal of the directing group. Detailed mechanistic investigations based on diverse analysis tools shed light on a novel mode of action. Abstract C7−H‐functionalized indoles are ubiquitous structural units of biological and pharmaceutical compounds for numerous antiviral agents...
Mon Jun 29, 2020 11:18
Isolation for activity : A solid co‐catalyst with monomeric Al sites for Ni‐catalyzed ethene dimerization was prepared by grafting Al(CH2 t Bu)3 on partially dehydroxylated silica and characterized by 27Al solid‐state NMR spectroscopy augmented by DFT computations. The efficient co‐catalytic properties of the material were attributed to the presence of monografted alkylaluminum species, representing 19 % of all Al species. Abstract A silica‐supported monomeric alkylaluminum co‐catalyst...
Mon Jun 29, 2020 11:18
Catalyzed by CuPd ’s arrow : CuPd nanoparticles are used as a robust catalyst for the electrochemical reductive allylic alkylation reaction in aqueous solution. Abstract An efficient CuPd nanoparticle (NP) catalyst (3 nm CuPd NPs deposited on carbon support) is designed for catalyzing electrochemical allylic alkylation in water/isopropanol (1:1 v/v) and 0.2 m KHCO3 solution at room temperature. The Pd catalysis was Pd/Cu composition‐dependent, and CuPd NPs with a Pd/Cu ratio close to one...
Mon Jun 29, 2020 11:18
Huisgen's 1,3‐Dipolar Cycloadditions to Fulvenes Proceed via Ambimodal [6+4]/[4+2] Transition States
Ring, ring : Computational studies with density functional theory (DFT) of Huisgen's 1,3‐dipolar cycloadditions and variants subsequently developed by others show that they involve ambimodal [6+4]/[4+2] transition states. Intriguingly, the ambimodal transition state with the nitrile ylide gives both products, favoring the [6+4] adduct, as found experimentally, while the diazomethane reaction is predicted to give only the [4+2] adduct. Abstract Huisgen's 1960 announcement of the concept...
Mon Jun 29, 2020 11:18
The synthesis of artificial mussel‐glue proteins with pH triggered cohesion control mechanism is described by extending the tyrosinase activated polymerization of peptides to sequences having specific modules for cohesion control. The high propensity of those sequence sections to adapt β‐sheets is temporarily suppressed by switch defects. This allows enzymatic activation and polymerization to proceed undisturbed. The β‐sheet formation is regained after polymerization by changing pH from 5.5 to 6.8,...
Sun Jun 28, 2020 17:00
Visual rhodopsin is an important archetype for G‐protein–coupled receptors, which are membrane proteins implicated in cellular signal transduction. Here we show experimentally for the first time that ~80 water molecules flood rhodopsin upon light absorption to form a solvent‐swollen active state. An influx of mobile water is sufficient for activating the photoreceptor, and is supported by molecular dynamics (MD) simulations. Combined force‐based measurements involving osmotic and hydrostatic pressure...
Sun Jun 28, 2020 16:55
We report here the first examples of linear conjugated organic polymer photocatalysts that produce oxygen from water after loading with cobalt and in the presence of an electron scavenger. The oxygen evolution rates, which are higher than for related organic materials, can be rationalized by a combination of the thermodynamic driving force for water oxidation, the light absorption of the polymer, and the aqueous dispersibility of the relatively hydrophilic polymer particles. We also used transient...
Sun Jun 28, 2020 16:54
Telomere length and oxidative stress variations in a murine model of Alzheimer’s disease progression
Abstract Alzheimer’s Disease (AD) is the most common cause of dementia and aging is its major risk factor. Changes in telomere length have been associated with aging and some degenerative diseases. Our aim was to explore some of the molecular changes caused by the progression of AD in a transgenic murine model (3xTg‐AD; B6; 129‐Psen1 <tm1Mpm> Tg (APPSwe, tauP301L) 1Lfa). Telomere length was assessed by qPCR in both brain tissue and peripheral blood cells and compared between three age groups:...
Sun Jun 28, 2020 18:17
Abstract The lack of propagation of signals through survived fibers is among the major reasons for functional loss after incomplete spinal cord injury (SCI). Our recent results of animal studies demonstrate that spinal electromagnetic stimulation (SEMS) can enhance transmission in damaged spinal cord and this type of modulation depends on the function of NMDA receptors at the neuronal networks below the injury level. Here, our pilot human study revealed that administration of repetitive SEMS induced...
Sun Jun 28, 2020 18:09
Abstract Evidence from both human and animal studies demonstrates the importance of social stress in the development of addiction‐related behavior. In rats, intermittent social defeat stress causes long‐lasting psychostimulant cross‐sensitization. Our recent data reveal heightened expression of AMPA receptor (AMPAR) GluA1 subunit in rat ventral tegmental area (VTA), which occurs concurrently with social stress‐induced amphetamine (AMPH) cross‐sensitization. In addition, social stress in rats induced...
Sun Jun 28, 2020 18:07
Abstract The study of the evolution of brain‐behavior relationships concerns understanding the causes and repercussions of cross‐ and within‐species variability. Understanding such variability is a main objective of evolutionary and cognitive neuroscience, and it may help explaining the appearance of psychopathological phenotypes. Although brain evolution is related to the progressive action of selection and adaptation through multiple paths (e.g., mosaic vs. concerted evolution, metabolic vs. structural...
Sun Jun 28, 2020 18:06
Telomere length and oxidative stress variations in a murine model of Alzheimer’s disease progression
Abstract Alzheimer’s Disease (AD) is the most common cause of dementia and aging is its major risk factor. Changes in telomere length have been associated with aging and some degenerative diseases. Our aim was to explore some of the molecular changes caused by the progression of AD in a transgenic murine model (3xTg‐AD; B6; 129‐Psen1 <tm1Mpm> Tg (APPSwe, tauP301L) 1Lfa). Telomere length was assessed by qPCR in both brain tissue and peripheral blood cells and compared between three age groups:...
Sun Jun 28, 2020 18:06
Abstract Purpose of Review Radiation therapy is an important treatment for patients with brain tumors but can have significant neurologic complications. This review highlights the broad spectrum of short-term and long-term neurologic complications that can occur in patients receiving cranial radiation therapy, and strategies to prevent and treat such complications. ...
Mon Jun 29, 2020 03:00
Unlike total hip arthroplasties, fixation method is not a predisposing risk factor for infections in total knee arthroplasty. This could be due to insufficient statistical power. Prophylactic precautions against other known risk factors for infection should still be clinically practiced. Abstract Background Prosthetic joint infection (PJI) is a serious complication of joint replacement surgeries. Surgeons often take extra measures to reduce the risk of PJI. Whilst many studies have compared...
Sun Jun 28, 2020 21:09
Surgical care has been impacted by the coronavirus disease 2019 pandemic, with concerns raised around surgical safety, especially in terms of laparoscopic versus open surgery. Due to potential aerosol transmission of severe acute respiratory syndrome coronavirus 2, precautions during aerosol‐generating procedures and production of surgical plume are paramount for the safety of surgical teams. From a rapid review on the topic, a working group of expert surgeons developed evidence‐based guidance...
Sun Jun 28, 2020 21:05
Abstract Background Cytoreductive surgery (CRS) for the management of peritoneal carcinomatosis (PC) can involve significant blood loss which necessitates the transfusion of blood products. This poses a particular challenge in the Jehovah's Witnesses population whose beliefs do not permit the transfusion of blood products or blood‐related derivatives. This report describes the experience of one institution performing CRS with hyperthermic intraperitoneal chemotherapy (HIPEC) for PC in Jehovah's...
Sun Jun 28, 2020 21:03
The overall morbidity rate was 20.6% (58/281) after early stoma closure as compared to 32% (111/347) after late stoma closure with relative difference ‐0.05 (95% confidence interval −0.22 to 0.11, P = 0.531). Abstract Background Recent evidence supports the safety of early reversal of a temporary stoma, within 14 days of construction. The aim of this systematic review and meta‐analysis was to evaluate the post‐operative morbidity and overall feasibility of early stoma reversal. ...
Sun Jun 28, 2020 20:09
Abstract According to the World Health Organization, cardiovascular diseases are the leading cause of death in the world. Therefore, early prevention of these diseases is a public health priority. Epidemiological data suggest that insomnia may be a modifiable risk factor for cardiovascular diseases. A randomized controlled trial in a sample of insomnia patients without cardiovascular disease was conducted to investigate the effects of insomnia treatment on early markers of cardiovascular diseases...
Sun Jun 28, 2020 15:59
Abstract The Covid‐19 pandemic has disrupted the habits of billions of people around the world. Lockdown at home is mandatory, forcing many families, each member with their own sleep–wake habits, to spend 24 hr a day together, continuously. Sleep is crucial for maintaining immune systems and contributes deeply to physical and psychological health. To assess sleep problems and use of sleeping pills, we conducted a cross‐sectional study of a representative sample of the general population in France....
Sun Jun 28, 2020 15:08
Sun Jun 28, 2020 19:08
Background and Objectives Recently, there has been a rapid increase in the incidences of melanoma, which represents a serious threat to human health. Generally, tumor‐microenvironment‐responsive nanoparticle‐based photothermal‐photodynamic combination therapy (PTT‐PDT) is characterized by intratumoral response and tumor targeting. In this study, we designed and synthesized hydrogen‐peroxide‐responsive protein biomimetic nanoparticles (MnO2‐ICG@BSA) for the treatment of melanoma. Study Design/Materials...
Sun Jun 28, 2020 20:20
Abstract The eukaryotic nucleus is not a homogenous single‐spaced but highly compartmentalized organelle, partitioned by various types of membrane‐less structures, including nucleoli, PML bodies, paraspeckles, DNA damage foci, and RNA clouds. Over the past few decades, these nuclear structures have been implicated in biological reactions such as gene regulation and DNA damage response and repair, and thought to provide “microenvironments” facilitating these reactions in the nucleus. Notably, an...
Sun Jun 28, 2020 18:35
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