Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com

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Δευτέρα 29 Ιουνίου 2020


Laser-Assisted Endoscopic Cricotracheal Stenosis Resection (CTSR) in Paediatric Congenital Cartilaginous Subglottic Stenosis
Subglottic stenosis (SGS) in children can be a congenital condition or acquired through injury such as from prolonged intubation. Surgeons face challenges in choosing the best SGS treatment for a particular patient because of variability in the success rate of each technique. Conventional open surgical resection and reconstruction have been proven effective but, in recent years, endoscopic surgery has become more prevalent as it eliminates the incision and reduces the surgery time and subsequent...
International Journal of Otolaryngology
Mon Jun 29, 2020 15:35
Vorbereitung zur Facharztprüfung HNO
HNO
Mon Jun 29, 2020 03:00
Selected Metal Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases as Potential Biomarkers for Tubulointerstitial Fibrosis in Children with Unilateral Hydronephrosis
Renal tubulointerstitial fibrosis caused by congenital ureteropelvic junction obstruction (UPJO) may lead to the development of obstructive nephropathy (ON) and the impairment of kidney function. Hence, the identification of early biomarkers of this condition might be of assistance in therapeutic decisions. This study evaluates serum and urinary metalloproteinases MMP-1, MMP-2, and MMP-9 and tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2 as potential biomarkers of ON in children with congenital...
Disease Markers
Mon Jun 29, 2020 15:35
Survivorship in immune therapy: Assessing toxicities, body composition and health-related quality of life among long-term survivors treated with antibodies to programmed death-1 receptor and its ligand
Publication date: August 2020Source: European Journal of Cancer, Volume 135Author(s): James Randall Patrinely, Arissa C. Young, Henry Quach, Grant R. Williams, Fei Ye, Run Fan, Leora Horn, Kathryn E. Beckermann, Erin A. Gillaspie, Jeffrey A. Sosman, Debra L. Friedman, Javid J. Moslehi, Douglas B. Johnson
European Journal of Cancer
Mon Jun 29, 2020 17:17
Hypothyroidism correlates with favourable survival prognosis in patients with brain metastatic cancer
Publication date: August 2020Source: European Journal of Cancer, Volume 135Author(s): Anna S. Berghoff, Christoph Wippel, Angelika M. Starzer, Nicolas Ballarini, Fabian Wolpert, Elisabeth Bergen, Peter Wolf, Ariane Steindl, Georg Widhalm, Brigitte Gatterbauer, Christine Marosi, Karin Dieckmann, Rupert Bartsch, Thomas Scherer, Franz Koenig, Michael Krebs, Michael Weller, Matthias Preusser
European Journal of Cancer
Mon Jun 29, 2020 17:17
Activity of cabozantinib after immune checkpoint blockade in metastatic clear-cell renal cell carcinoma
Publication date: August 2020Source: European Journal of Cancer, Volume 135Author(s): Bradley A. McGregor, Aly-Khan A. Lalani, Wanling Xie, John A. Steinharter, Ziad E. Bakouny, Dylan J. Martini, Justin H. Fleischer, Sarah Abou-Alaiwi, Amin Nassar, Pier V. Nuzzo, Marina D. Kaymakcalan, David A. Braun, Xiao X. Wei, Lauren C. Harshman, Mehmet A. Bilen, Toni K. Choueiri
European Journal of Cancer
Mon Jun 29, 2020 17:17
Chemoradiotherapy efficacy is predicted by intra-tumour CD8+/FoxP3+ double positive T cell density in locally advanced N2 non–small-cell lung carcinoma
Publication date: August 2020Source: European Journal of Cancer, Volume 135Author(s): G. Boulle, Y. Velut, A. Mansuet-Lupo, L. Gibault, H. Blons, L. Fournel, A. Boni, I. Cremer, M. Wislez, V. Duchatelle, J. Trédaniel, S.A. Hammond, R. Herbst, M. Alifano, P. Giraud, D. Damotte
European Journal of Cancer
Mon Jun 29, 2020 17:17
Stability of nivolumab in its original vials after opening and handing in normal saline bag for intravenous infusion
Publication date: August 2020Source: European Journal of Cancer, Volume 135Author(s): G. Le Guyader, V. Vieillard, S. Mouraud, B. Do, A. Marabelle, M. Paul
European Journal of Cancer
Mon Jun 29, 2020 17:17
Comparative analysis of docetaxel: physical and chemical characterisation of Taxotère® and generics
Publication date: August 2020Source: European Journal of Cancer, Volume 135Author(s): Roy Pétronille, Do Bernard, Le Guyader Guillaume, Viellard Victoire, Fleury Thomas, Conq Jérôme, Da Costa Eloïse, Pierron Gérard, Souquere Sylvie, Solgadi Audrey, Lemare François, Delaloge Suzette, Paul Muriel, Annereau Maxime
European Journal of Cancer
Mon Jun 29, 2020 17:17
Identification of epithelial-mesenchymal transition-related circRNA-miRNA-mRNA ceRNA regulatory network in breast cancer
Publication date: Available online 29 June 2020Source: Pathology - Research and PracticeAuthor(s): Meijie Sang, Ming Wu, Lingjiao Meng, Yang Zheng, Lina Gu, Fei Liu, Meixiang Sang
ScienceDirect Publication: Pathology - Research and Practice
Mon Jun 29, 2020 17:02
HER2 genomic heterogeneity is a frequent event in gastroesophageal adenocarcinoma and correlates with tumor morphology
Publication date: Available online 29 June 2020Source: Pathology - Research and PracticeAuthor(s): Raquel Machado-Neves, João Vale, Catarina Eloy, António Polónia
ScienceDirect Publication: Pathology - Research and Practice
Mon Jun 29, 2020 17:02
MiR-135a-5p inhibits vascular smooth muscle cells proliferation and migration by inactivating FOXO1 and JAK2 signaling pathway
Publication date: Available online 28 June 2020Source: Pathology - Research and PracticeAuthor(s): Dong Li, An Yi
ScienceDirect Publication: Pathology - Research and Practice
Mon Jun 29, 2020 17:02
Thickness change of masseter muscles and the surrounding soft tissues in female patients during orthodontic treatment: a retrospective study
Abstract Background Facial esthetics is a major concern of orthodontic patients. This study aims to evaluate orthodontic treatment-related thickness changes of the masseter muscles and surrounding soft tissues and the potential factors that would influence these changes during orthodontic treatment in female adults. Methods Forty-two...
Latest Results for BMC Oral Health
Mon Jun 29, 2020 03:00
“Clinical comparison of bond failure rate between two types of mandibular canine-canine bonded orthodontic retainers- a randomized clinical trial”
Abstract Background Bonded retainers are widely used as they are esthetically pleasing, easily acceptable, provide greater stability, compliance free and causes no soft tissue irritation and speech problems. Though, fracture and bond failure are their shortcomings. Therefore, the objectives of this study were to evaluate the number of bond failures and type of failure pattern between two types of mandibular canine-canine bonded...
Latest Results for BMC Oral Health
Mon Jun 29, 2020 03:00
Alveolar ridge preservation and primary stability as influencing factors on the transfer accuracy of static guided implant placement: a prospective clinical trial
Abstract Background The aim of this prospective clinical study was to investigate differences between virtually planned and clinically achieved implant positions in completely template-guided implant placements as a function of the tooth area, the use of alveolar ridge preservation, the implant length and diameter, and the primary implant stability. Methods...
Latest Results for BMC Oral Health
Mon Jun 29, 2020 03:00
Experimental pain and fatigue induced by excessive chewing
Abstract Background The study was aiming to optimize excessive gum chewing as an experimental model to induce jaw muscle pain and fatigue similar to those in painful TMDs with durations that would allow immediate investigations of jaw-motor function. Further, if any sex differences would be detected in the expression of pain. Methods ...
Latest Results for BMC Oral Health
Mon Jun 29, 2020 03:00
Real-Time Monitoring of Chemotherapy Side-Effects in Patients With Gastrointestinal Cancers, RT-CAMSS Study
Conditions:   Clinical Stage 0 Esophageal Adenocarcinoma AJCC v8;   Clinical Stage 0 Esophageal Squamous Cell Carcinoma AJCC v8;   Clinical Stage 0 Gastric Cancer AJCC v8;   Clinical Stage I Esophageal Adenocarcinoma AJCC v8;   Clinical Stage I Esophageal Squamous Cell Carcinoma AJCC v8;   Clinical Stage I Gastric Cancer AJCC v8;   Clinical Stage II Esophageal Adenocarcinoma AJCC v8;   Clinical Stage II Esophageal Squamous Cell Carcinoma AJCC v8;   Clinical Stage II Gastric Cancer AJCC v8;   Clinical...
ClinicalTrials
Mon Jun 29, 2020 16:32
Design and synthesis of 4-[4-formyl-3-(2-naphthyl)pyrazol-1-yl]benzoic acid derivatives as potent growth inhibitors of drug-resistant <i>Staphylococcus aureus</i>
The Journal of Antibiotics, Published online: 29 June 2020; doi:10.1038/s41429-020-0341-2Design and synthesis of 4-[4-formyl-3-(2-naphthyl)pyrazol-1-yl]benzoic acid derivatives as potent growth inhibitors of drug-resistant Staphylococcus aureus
The Journal of Antibiotics - Issue - nature.com science feeds
Mon Jun 29, 2020 03:00
Design and synthesis of 4-[4-formyl-3-(2-naphthyl)pyrazol-1-yl]benzoic acid derivatives as potent growth inhibitors of drug-resistant <i>Staphylococcus aureus</i>
The Journal of Antibiotics - Issue - nature.com science feeds
Mon Jun 29, 2020 03:00
Selective cytotoxicity of marine-derived fungal metabolite (3<i>S</i>,6<i>S</i>)-3,6-dibenzylpiperazine-2,5-dione against cancer cells adapted to nutrient starvation
The Journal of Antibiotics - Issue - nature.com science feeds
Thu Jun 25, 2020 03:00
Bitter compounds in two <i>Tricholoma</i> species, <i>T. aestuans</i> and <i>T. virgatum</i>
The Journal of Antibiotics - Issue - nature.com science feeds
Tue Jun 23, 2020 03:00
Bone up on spinal osseous lesions: a case review series
Abstract Spinal osseous neoplasms are frequently encountered and can be challenging when present as solitary lesions. Familiarity with the range of benign and malignant spinal pathology can help the radiologist formulate a comprehensive differential diagnosis. This article focuses on the spectrum of extradural spinal tumors, accounting for the majority of primary spinal tumors, by comparing the epidemiology, pathophysiology, clinical presentation, and characteristic imaging...
Imaging
Mon Jun 29, 2020 03:00
Fibrovascular Tumor-Like Lesions of the Facial Nerve
Background: Facial nerve tumors (FNTs) are relatively rare benign lesions that arise from any segment of the facial nerve (FN). About half of all patients present with FN dysfunction, mainly long-standing or progressive facial paralysis. Diagnosis of an FNT is usually based on radiological imaging and confirmed by histological study. Most reported cases of FNTs are schwannomas and hemangiomas. Objectives: The aim of this study was to review 4 cases of lesions with clinical, radiological, and surgical...
Audiology and neurotology
Mon Jun 29, 2020 09:39
Linguistic features and automatic classifiers for identifying mild cognitive impairment and dementia
Publication date: January 2021Source: Computer Speech & Language, Volume 65Author(s): Laura Calzà, Gloria Gagliardi, Rema Rossini Favretti, Fabio Tamburini
Computer Speech & Language
Mon Jun 29, 2020 15:16
Removal of a Baerveldt Glaucoma Implant and Fibrous Adhesion for Refractory Mechanical Strabismus
Although strabismus is a well-known complication of glaucoma implant surgery, its surgical treatment is still challenging. We present a case with refractory strabismus after Baerveldt glaucoma implant (BGI) surgery, which was not sufficiently improved by strabismus surgery, but by removal of the BGI and fibrous adhesion. The patient was a 35-year-old woman who had multiple surgeries for secondary glaucoma. She had severe limitations of the movement of her right eye and binocular diplopia in all gaze...
Case Reports in Ophthalmology
Mon Jun 29, 2020 10:42
Small Symptomatic Unilateral Choroidal Osteoma Diagnosed with Enhanced-Depth Imaging Optical Coherence Tomography and Thin-Slice Computed Tomography: 2 Clinical Cases
Background: Choroidal osteoma is a rare, benign, ossifying intraocular tumor of unknown etiology. While patients with choroidal osteoma usually show distinct large yellowish subretinal lesions, some could have small lesions, making the differential diagnosis difficult. We experienced 2 cases of small symptomatic unilateral osteoma approximately 1.0-mm disc diameter in size. Methods: Retrospective medical charts of 2 patients with small symptomatic unilateral osteoma were reviewed. Fundus examination,...
Case Reports in Ophthalmology
Mon Jun 29, 2020 10:38
Los peores asesinos (Entrevista a Mark Olshaker)
Mark OlshakerEn nuestra anterior entrevista al Dr. Russil Durrant, abordábamos el siempre presente asunto de la violencia. Por mucho que simpaticemos con el pacifismo y la no violencia, lo haremos desde un diseño biológico que lleva inserta la violencia no sólo como último recurso, sino como un recurso cotidiano del que apenas somos conscientes. Sea como sea hay una gran variabilidad en la violencia que los seres humanos ejercen en sus respectivas existencias, en particular sobre otros seres humanos.Si...
La nueva Ilustración Evolucionista / The new Evolutionary Enlightenment
Mon Jun 29, 2020 14:07
Comparative metabolomic analyses of Dendrobium officinale Kimura et Migo responding to UV-B radiation reveal variations in the metabolisms associated with its bioactive ingredients
Background Dendrobium officinale Kimura et Migo, a member of the genus Dendrobium, is a traditional Chinese medicine with high commercial value. The positive roles of UV-B radiation on active ingredient metabolism in various medicinal plants have been studied. However, the metabolic responses of D. officinale stems to UV-B treatment is largely unknown. Methods An untargeted metabolomics method was used to investigate...
PeerJ Computer Science
Mon Jun 29, 2020 03:00
The genome of the butternut canker pathogen, Ophiognomonia clavigignenti-juglandacearum shows an elevated number of genes associated with secondary metabolism and protection from host resistance responses
Ophiognomonia clavigignenti-juglandacearum (Oc-j) is a plant pathogenic fungus that causes canker and branch dieback diseases in the hardwood tree butternut, Juglans cinerea. Oc-j is a member of the order of Diaporthales, which includes many other plant pathogenic species, several of which also infect hardwood tree species. In this study, we sequenced the genome of Oc-j and achieved a high-quality assembly and delineated its phylogeny within the Diaporthales order using a genome-wide multi-gene approach....
PeerJ Computer Science
Mon Jun 29, 2020 03:00
A new species of freshwater crab genus Fredius Pretzmann, 1967 (Crustacea: Brachyura: Pseudothelphusidae) from a naturally isolated orographic forest enclave within the semiarid Caatinga in Ceará, northeastern Brazil
A new species of freshwater crab, Fredius ibiapaba, is described and illustrated from a mid-altitude forested patch in Ipú (Ibiapaba plateau, Ceará, northeastern Brazil), between 635 to 782 m. The new species can be separated from its congeners by the morphology of its first gonopod: proximal half remarkably swollen, sloping abruptly downwards distally to a nearly right-angular shoulder; mesial lobe much smaller than cephalic spine; cephalic lobe moderately developed; auxiliary lobe lip, delimiting...
PeerJ Computer Science
Mon Jun 29, 2020 03:00
Shannon diversity index: a call to replace the original Shannon’s formula with unbiased estimator in the population genetics studies
Background The Shannon diversity index has been widely used in population genetics studies. Recently, it was proposed as a unifying measure of diversity at different levels—from genes and populations to whole species and ecosystems. The index, however, was proven to be negatively biased at small sample sizes. Modifications to the original Shannon’s formula have been proposed to obtain an unbiased estimator. Methods In...
PeerJ Computer Science
Mon Jun 29, 2020 03:00
A preoperative nomogram for sepsis in percutaneous nephrolithotomy treating solitary, unilateral and proximal ureteral stones
Background Postoperative sepsis is a lethal complication for percutaneous nephrolithotomy (PCNL). An early predictive model combined local and systemic conditions is urgently needed to predict infectious events. We aim to determine the preoperative predictors of sepsis after PCNL in patients with unilateral, solitary, and proximal ureteral stones. Methods A total of 745 patients who underwent PCNL between January 2012 and December 2018 were retrospectively enrolled. Sepsis was defined...
PeerJ Computer Science
Mon Jun 29, 2020 03:00
Using Bumble Bee Watch to investigate the accuracy and perception of bumble bee (Bombus spp.) identification by community scientists
Community science programs provide an opportunity to gather scientific data to inform conservation policy and management. This study examines the accuracy of community science identifications submitted to the North American Bumble Bee Watch program on a per species level and as compared to each species’ conservation status, as well as users (members of the public) and experts (those with expertise in the field of bumble bee biology) perceived ease of species identification. Photos of bumble bees...
PeerJ Computer Science
Mon Jun 29, 2020 03:00
Gait characteristics in individuals with Parkinson’s disease during 1-minute treadmill walking
Background No previous study has examined the age-dependent characteristics of gait in individuals between 50 and 79 years simultaneously in healthy individuals and individuals with Parkinson’s disease (PD) over continuous gait cycles. This study aimed to investigate age-related differences in gait characteristics on individuals age ranged 50–79 years, including individuals with PD, during a 1-minute treadmill walking session. Additionally, we aimed to investigate the differences associated with...
PeerJ Computer Science
Mon Jun 29, 2020 03:00
Hemogram data as a tool for decision-making in COVID-19 management: applications to resource scarcity scenarios
Background COVID-19 pandemics has challenged emergency response systems worldwide, with widespread reports of essential services breakdown and collapse of health care structure. A critical element involves essential workforce management since current protocols recommend release from duty for symptomatic individuals, including essential personnel. Testing capacity is also problematic in several countries, where diagnosis demand outnumbers available local testing capacity. Purpose This...
PeerJ Computer Science
Mon Jun 29, 2020 03:00
Integrative analysis of competitive endogenous RNA network reveals the regulatory role of non-coding RNAs in high-glucose-induced human retinal endothelial cells
Background Increasing evidence has suggested that non-coding RNAs (ncRNAs) play critical roles in the pathogenesis of diabetic retinopathy (DR), but their underlying mechanisms remain unclear. The purpose of this study was to determine latent key genes and to structure a competing endogenous RNA (ceRNA) regulatory network to discover the potential molecular mechanisms governing the effects of high glucose on human retinal endothelial cells (HRECs). Methods We obtained microarray data...
PeerJ Computer Science
Mon Jun 29, 2020 03:00
Correlative Multicentric Analysis of Dimensions of Nasopharynx and Adenoid Size, and its Burden in Otitis Media with Effusion: An Indian Scenario
Abstract Diseases of adenoids are commonly observed in children. It indirectly leads to pathology in the middle ear cleft. It has been demonstrated both by radiological techniques and middle ear pressure studies that adenoids can and do obstruct the Eustachian Tube. The Adenoid—Nasopharyngeal Ratio (ANR), can offer a simple arithmetic measure of nasopharyngeal obstruction. Coupled with tympanometry, it also predicts the degree to which the middle ear is affected. Multicentric...
Otolaryngology Indian
Mon Jun 29, 2020 03:00
Silencing the intestinal GUCY2C tumor suppressor axis requires APC loss of heterozygosity
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Cancer Biology & Therapy: Table of Contents: Taylor and Francis
Sun Jun 28, 2020 10:03
Quality of Regional Nodal Irradiation Plans in Breast Cancer Patients Across a Large Network – Can We Translate Results from Randomized Trials into the Clinic?
Publication date: Available online 29 June 2020Source: Practical Radiation OncologyAuthor(s): Diane C. Ling, Bryanna L. Moppins, Colin E. Champ, Vikram C. Gorantla, Sushil Beriwal
Practical Radiation Oncology
Mon Jun 29, 2020 14:24

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