Journal of Adolescent and Young Adult Oncology, Ahead of Print.
Thu Jun 25, 2020 10:00
Stem Cells and Development, Ahead of Print.
Sat Jun 27, 2020 10:00
In insect species like Drosophila melanogaster, the ability to evolve greater resistance or evolution of certain traits under specific environmental conditions leads to energy trade-offs with other important life-history traits. A number of studies from multiple fields have documented the life-history associated cost. However, no known studies have assessed the life-history associated cost with evolved reproductive traits and increase egg viability in cold shock selected population. To explore this,...
Mon Jun 29, 2020 03:00
The DAN gene family (DAN, Differential screening-selected gene Aberrant in Neuroblastoma) is a group of genes that is expressed during development and plays fundamental roles in limb bud formation and digitation, kidney formation and morphogenesis and left-right axis specification. During adulthood the expression of these genes are associated with diseases, including cancer. Although most of the attention to this group of genes has been dedicated to understanding its role in physiology and development,...
Mon Jun 29, 2020 03:00
Most secondarily non-photosynthetic eukaryotes have retained residual plastids whose physiological role is often still unknown. One such example is Euglena longa, a close non-photosynthetic relative of Euglena gracilis harbouring a plastid organelle of enigmatic function. By mining transcriptome data from E. longa we finally provide an overview of metabolic processes localized to its elusive plastid. The organelle plays no role in biosynthesis of isoprenoid precursors and fatty acids, and has a very...
Mon Jun 29, 2020 03:00
Opsin receptors mediate the visual process in animals and their evolutionary history can provide precious hints on the ecological factors that underpin their diversification. Here we mined the genomes of more than 60 Dipteran species and reconstructed the evolution of their opsin genes in a phylogenetic framework. Our phylogenies indicate that dipterans possess an ancestral set of five core opsins which have undergone several lineage-specific events including an independent expansion of low wavelength...
Mon Jun 29, 2020 03:00
In order to explore nonsynonymous mutations and deletions in the spike (S) protein of SARS CoV 2, we comprehensively analyzed 35,750 complete S protein gene sequences from across six continents and five climate zones around the world, as documented in the GISAID database as of June 24th, 2020. Through a custom Python based pipeline for analyzing mutations, we identified 27,801 (77.77 % of spike sequences) mutated strains compared to Wuhan Hu 1 strain. 84.40% of these strains had only single amino...
Mon Jun 29, 2020 03:00
Global climate change has the potential to devastate biological systems as organisms are exposed to novel temperature regimes. Increases in annual mean temperature have been accompanied by disproportionate rates of change in temperature across seasons, and winter is the season warming most rapidly. Yet, to our knowledge, no research has characterized the direct effects of winter warming on the biology of overwintering organisms. Here, we investigated the effects of winter warming stress on internal...
Mon Jun 29, 2020 03:00
Ale brewing yeast are the result of admixture between diverse strains of Saccharomyces cerevisiae, resulting in a heterozygous tetraploid that has since undergone numerous genomic rearrangements. As a result, comparisons between the genomes of modern related ale brewing strains show both extensive aneuploidy and mitotic recombination that has resulted in a loss of intragenomic diversity. Similar patterns of intraspecific admixture and subsequent selection for one haplotype have been seen in many...
Mon Jun 29, 2020 03:00
Understanding the genetic basis of species differences is a major goal in evolutionary biology. Pigmentation divergence between Drosophila species often involves genetic changes in pigmentation candidate genes that pattern the body and wings, but it remains unclear how these changes affect pigmentation evolution in multiple body parts between the same diverging species. Drosophila elegans and D. gunungcola show pigmentation differences in the thorax, legs, and wings, with D. elegans exhibiting male-specific...
Mon Jun 29, 2020 03:00
Inferring the frequency and mode of hybridization among closely related organisms is an important step for understanding the process of speciation and can help to uncover reticulated patterns of phylogeny more generally. Phylogenomic methods to test for the presence of hybridization come in many varieties and typically operate by leveraging expected patterns of genealogical discordance in the absence of hybridization. An important assumption made by these tests is that the data (genes or SNPs) are...
Mon Jun 29, 2020 03:00
Horizontal gene transfer (HGT), the movement of heritable materials between distantly related organisms, is crucial in eukaryotic evolution. However, the scale of HGT in choanoflagellates, the closest unicellular relatives of metazoans, and its possible roles in the evolution of animal multicellularity remains unexplored. We identified 703 potential HGTs in the S. rosetta genome using sequence-based tests. The majority of which were orthologous to bacterial lineages, yet displayed genomic features...
Mon Jun 29, 2020 03:00
Mitoribosomes synthesize essential proteins encoded in the mitochondrial genome. They consist of the ribosomal RNA and protein components, coordinated assembly of which is critical for function. Divergent mitoribosomes with reduced RNA and increased protein mass were described in Trypanosoma brucei, a mammalian parasite causing African Trypanosomiases. Here, we report that the large subunit of T. brucei mitoribosome requires at least 15 biogenesis factors, which we characterized in complex with an...
Mon Jun 29, 2020 03:00
Despite its economic importance as a new biofuel resource, little work has been done on the large-scale phylogenetics of Miscanthus. Twenty- three complete Miscanthus chloroplasts were assembled and annotated. A phylogeny was performed with these assemblies, which shows the relationships between the main Miscanthus species and sub-species. The phylogeny demonstrates that there is no meaningful distinction between Miscanthus floridulus and Miscanthus transmorrisonensis as the accessions are not distinct....
Mon Jun 29, 2020 03:00
Mutations that alter cellular receptor binding of influenza hemagglutinin (HA) have profound effects on immune escape. Despite its high mutation rate, it is not fully understood why human influenza HA displays limited antigenic diversity across circulating viruses. We applied phylogenetic analysis and phylodynamic modeling to understand the evolutionary and epidemiological effects of binding avidity adaptation in humans using net charge as a marker for receptor binding avidity. Using 686 human influenza...
Mon Jun 29, 2020 03:00
Genetic assimilation - the evolutionary process by which an ancestral environmentally sensitive phenotype is made constitutive - is a fundamental concept in biology. Its evolutionary relevance is debated, and our understanding of its prevalence, and underlying genetics and molecular mechanisms, is poor. Matricidal hatching is an extreme form of maternal provisioning induced by adverse conditions, which varies among Caenorhabditis elegans populations. We identified wild isolates, sampled from natural...
Mon Jun 29, 2020 03:00
We investigated genetic variation at 37 newly-developed microsatellite loci in populations of the tsetse fly Glossina fuscipes fuscipes captured from the upper and lower reaches of a single hydrographical network within an endemic Human African Trypanosomiasis focus. Our primary aim was to assess the impact of vector control using insecticide-treated baits (Tiny Targets) on genetic structure. We initially used STRUCTURE to delineate geographical boundaries of two stable ancestral reference populations...
Mon Jun 29, 2020 03:00
The recognition and description of new diseases often resemble the parable of the blind men and the elephant, with each declaring that the part of the beast they have touched fully defines it. As the coronavirus disease 2019 (Covid-19) pandemic has evolved, case reports have appeared describing…
Mon Jun 29, 2020 03:00
The coronavirus disease 2019 (Covid-19) pandemic has caused catastrophic disease worldwide, although children have been relatively spared. Severe lung involvement with acute respiratory failure is the most common complication of Covid-19 in adults, but many have complications in multiple organs,…
Mon Jun 29, 2020 03:00
High Phosphoglycerate Dehydrogenase Expression Induces Stemness and Aggressiveness in Thyroid Cancer
Thyroid, Ahead of Print.
Fri Jun 26, 2020 10:00
Thyroid, Ahead of Print.
Thu Jun 25, 2020 10:00
Thyroid, Ahead of Print.
Thu Jun 25, 2020 10:00
Thyroid, Ahead of Print.
Thu Jun 25, 2020 10:00
Future Oncology, Ahead of Print.
Mon Jun 29, 2020 10:25
Future Oncology, Ahead of Print.
Mon Jun 29, 2020 09:21
Future Oncology, Ahead of Print.
Mon Jun 29, 2020 09:07
Surgical Infections, Ahead of Print.
Fri Jun 26, 2020 10:00
Surgical Infection Society Guidelines for Antibiotic Use in Patients with Traumatic Facial Fractures
Surgical Infections, Ahead of Print.
Fri Jun 26, 2020 10:00
Journal of Neurotrauma, Ahead of Print.
Fri Jun 26, 2020 10:00
Expression of Angiopoietins and Angiogenic Signaling Pathway Molecules in Chronic Subdural Hematomas
Journal of Neurotrauma, Ahead of Print.
Fri Jun 26, 2020 10:00
Journal of Neurotrauma, Ahead of Print.
Fri Jun 26, 2020 10:00
Journal of Neurotrauma, Ahead of Print.
Thu Jun 25, 2020 10:00
Journal of Neurotrauma, Ahead of Print.
Thu Jun 25, 2020 10:00
Tissue Engineering Part A, Ahead of Print.
Fri Jun 26, 2020 10:00
Tissue Engineering Part A, Ahead of Print.
Fri Jun 26, 2020 10:00
Tissue Engineering Part A, Ahead of Print.
Fri Jun 26, 2020 10:00
Tissue Engineering Part A, Ahead of Print.
Fri Jun 26, 2020 10:00
Tissue Engineering Part A, Ahead of Print.
Fri Jun 26, 2020 10:00
Tissue Engineering Part A, Ahead of Print.
Thu Jun 25, 2020 10:00
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου