Publication date: Available online 7 July 2020Source: BrachytherapyAuthor(s): Gustavo R. Sarria, Elena Sperk, Frederik Wenz, Frank Schneider, Yasser Abo-Madyan, Frank A. Giordano, Michael Ehmann
Wed Jul 08, 2020 13:52
Related Articles Private Payer and Medicare Coverage for Circulating Tumor DNA Testing: A Historical Analysis of Coverage Policies From 2015 to 2019. J Natl Compr Canc Netw. 2020 Jul;18(7):866-872 Authors: Douglas MP, Gray SW, Phillips KA Abstract BACKGROUND: Clinical adoption of the sequencing of circulating tumor DNA (ctDNA) for cancer has rapidly increased in recent years. This sequencing is used to select targeted therapy and monitor nonresponding...
Wed Jul 08, 2020 15:18
Related Articles NCCN Policy Summit: Defining, Measuring, and Applying Quality in an Evolving Health Policy Landscape and the Implications for Cancer Care. J Natl Compr Canc Netw. 2020 Jul;18(7):820-824 Authors: Bandini LAM, Gallo L, Johnson T, Martin K, Schatz AA, Adelson K, Loy BA, Walters RS, Wong T, Carlson RW Abstract Quality measurement is a critical component of advancing a health system that pays for performance over volume. Although...
Wed Jul 08, 2020 15:18
Related Articles A phase II, multicenter, two cohort study of 160 mg osimertinib in EGFR T790M-positive non-small cell lung cancer patients with brain metastases or leptomeningeal disease who progressed on prior EGFR TKI therapy. Ann Oncol. 2020 Jul 04;: Authors: Park S, Lee MH, Seong M, Kim ST, Kang JH, Cho BC, Lee KH, Cho EK, Sun JM, Lee SH, Ahn JS, Park K, Ahn MJ Abstract BACKGROUND: Up to 40% of patients with non-small cell lung cancer (NSCLC)...
Wed Jul 08, 2020 15:18
Related Articles Scientia Potentia Est: How the Italian World of Oncology Changes in the COVID-19 Pandemic. JCO Glob Oncol. 2020 Jul;6:1017-1023 Authors: Ballatore Z, Bastianelli L, Merloni F, Ranallo N, Cantini L, Marcantognini G, Berardi R Abstract PURPOSE: After coronavirus disease 2019 (COVID-19) was declared a pandemic by the WHO, a response from the Italian Health System to react to an unprecedented condition became necessary and sudden....
Wed Jul 08, 2020 15:18
Related Articles Quantifying the psychosocial impact of a weekend retreat on adolescent and young adult (AYA) oncology patients. J Psychosoc Oncol. 2020 Jul 07;:1-12 Authors: Antonetti C, Stromberg SE, Costello A, Faith MA, Shaw PH Abstract OBJECTIVE: This study aimed to determine if AYA oncology patients experienced a quantifiable improvement in psychosocial outcomes after attending a weekend retreat with their peers. METHODS: AYA...
Wed Jul 08, 2020 15:18
Related Articles Incorporating a clinical oncology pharmacist into an ambulatory care pharmacy in pediatric hematology-oncology and transplant clinic: Assessment and significance. J Oncol Pharm Pract. 2020 Jul 06;:1078155220934167 Authors: Ali K, Al-Quteimat O, Naseem R, Malhi SM, Wajdi M, Jahan N, Ansari SH, Shamsi TS Abstract BACKGROUND: Beta thalassemia patients, post-bone marrow transplant, and leukemia patients require long term therapy...
Wed Jul 08, 2020 15:18
Related Articles SOLTI-1503 PROMETEO TRIAL: combination of talimogene laherparepvec with atezolizumab in early breast cancer. Future Oncol. 2020 Jul 07;: Authors: Pascual T, Cejalvo JM, Oliveira M, Vidal M, Vega E, Ganau S, Julve A, Zamora E, Miranda I, Delgado A, Bermejo B, la Cruz-Merino L, Juan M, Ferrero-Cafiero JM, Canes J, Gonzalez X, Villagrasa P, Prat A Abstract New treatment strategies such as immune checkpoint inhibitors and oncolytic...
Wed Jul 08, 2020 15:18
Related Articles The expression and clinical significance of B7-H3 and miR-145 in lung cancer patients with malignant pleural effusion. Eur Rev Med Pharmacol Sci. 2020 Jun;24(12):6759-6766 Authors: Huang L Abstract OBJECTIVE: To investigate the expression and clinical significance of costimulatory molecule B7-H3 and microRNA-145 (miR-145) in lung cancer patients with malignant pleural effusion. PATIENTS AND METHODS: A total of 100 cases...
Wed Jul 08, 2020 15:18
Related Articles LncRNA DANCR regulates osteosarcoma migration and invasion by targeting miR-149/MSI2 axis. Eur Rev Med Pharmacol Sci. 2020 Jun;24(12):6551-6560 Authors: Zhang W, Li JZ, Tai QY, Tang JJ, Huang YH, Gao SB Abstract OBJECTIVE: As a new LncRNA, anti-differentiated non-coding RNA (DANCR) plays an important role in tumorigenesis and development, and its molecular mechanism in osteosarcoma is unclear. In this study, by investigating...
Wed Jul 08, 2020 15:18
Related Articles Optimizing health literacy to facilitate reproductive health decision-making in adolescent and young adults with cancer. Pediatr Blood Cancer. 2020 Jul 06;:e28476 Authors: Nahata L, Anazodo A, Cherven B, Logan S, Meacham LR, Meade CD, Zarnegar-Lumley S, Quinn GP Abstract Despite being considered "standard of care" by many organizations, fertility and reproductive health communications and counseling practices remain inconsistent...
Wed Jul 08, 2020 15:18
Related Articles The Landmark Series: Neuroendocrine Tumor Liver Metastases. Ann Surg Oncol. 2020 Jul 06;: Authors: Gangi A, Howe JR Abstract BACKGROUND: Neuroendocrine tumors are becoming increasingly prevalent, with many patients presenting with or developing metastatic disease to the liver. METHODS: In this landmark series paper, we highlight the critical studies that have defined the surgical management of neuroendocrine tumor liver...
Wed Jul 08, 2020 15:18
Related Articles Supportive care needs and service use during palliative care in family caregivers of patients with advanced cancer: a prospective longitudinal study. Support Care Cancer. 2020 Jul 06;: Authors: Ullrich A, Marx G, Bergelt C, Benze G, Zhang Y, Wowretzko F, Heine J, Dickel LM, Nauck F, Bokemeyer C, Oechsle K Abstract PURPOSE: This study aimed to investigate the supportive care needs of family caregivers (FCs) of advanced cancer...
Wed Jul 08, 2020 15:18
Related Articles Preparing Trainees to Deliver High-Value and Cost-Conscious Care in Hematology. Curr Hematol Malig Rep. 2020 Jul 06;: Authors: Nagle SJ, Aakhus E Abstract PURPOSE OF REVIEW: Despite national-level directives to reduce healthcare waste and promote high-value care (HVC), clinical educators struggle to equip trainees with the knowledge and skills needed to practice value-based care. In this review, we analyze ongoing efforts in...
Wed Jul 08, 2020 15:18
Related Articles Conducting research in Radiation Oncology remotely during the COVID-19 pandemic: Coping with isolation. Clin Transl Radiat Oncol. 2020 Sep;24:53-59 Authors: Dhont J, Di Tella M, Dubois L, Aznar M, Petit S, Spałek M, Boldrini L, Franco P, Bertholet J Abstract Introduction: With the COVID-19 pandemic, individuals have been forced to follow strict social isolation guidelines. While crucial to control the pandemic, isolation might...
Wed Jul 08, 2020 15:18
Related Articles Multiple myeloma: Current and future management in the aging population. Maturitas. 2020 Aug;138:8-13 Authors: Fotiou D, Ntanasis-Stathopoulos I, Gavriatopoulou M, Dimopoulos MA Abstract The increasing lifespan of the world population and the novel therapeutic combinations for the treatment of multiple myeloma (MM), which are more efficacious and safer, make the question of how to manage the older patient with MM increasingly...
Wed Jul 08, 2020 13:50
Related Articles General practitioners' perceptions of compassionate communities: a qualitative study. BMC Palliat Care. 2020 Jul 06;19(1):97 Authors: Abbey E, Craig C, Mayland CR Abstract BACKGROUND: General Practitioners (GPs) face challenges when providing palliative care, including an ageing, multimorbid population, and falling GP numbers. A 'public health palliative care' approach, defined as "working with communities to improve people's...
Wed Jul 08, 2020 13:50
Related Articles Oncolytic vaccinia virus GLV-1h68 exhibits profound antitumoral activities in cell lines originating from neuroendocrine neoplasms. BMC Cancer. 2020 Jul 06;20(1):628 Authors: Kloker LD, Berchtold S, Smirnow I, Beil J, Krieg A, Sipos B, Lauer UM Abstract BACKGROUND: Oncolytic virotherapy is an upcoming treatment option for many tumor entities. But so far, a first oncolytic virus only was approved for advanced stages of malignant...
Wed Jul 08, 2020 13:50
Related Articles Corrigendum. Future Oncol. 2020 Jul 06;: Authors: PMID: 32631101 [PubMed - as supplied by publisher]
Wed Jul 08, 2020 13:50
Related Articles Measuring Reactive Sulfur Species and Thiol Oxidation States: Challenges and Cautions in Relation to Alkylation Based Protocols. Antioxid Redox Signal. 2020 Jul 06;: Authors: Nagy P, Doka E, Ida T, Akaike T Abstract SIGNIFICANCE: Redox biology is gaining ground in research related to human physiology (metabolism, signaling), pathophysiology (cancer, cardiovascular disease, neurodegeneration) and toxicology (radiation or xenobiotic-induced...
Wed Jul 08, 2020 13:50
Related Articles IGF-1R/mTOR Targeted Therapy for Ewing Sarcoma: A Meta-Analysis of Five IGF-1R-Related Trials Matched to Proteomic and Radiologic Predictive Biomarkers. Cancers (Basel). 2020 Jul 02;12(7): Authors: Amin HM, Morani AC, Daw NC, Lamhamedi-Cherradi SE, Subbiah V, Menegaz BA, Vishwamitra D, Eskandari G, George B, Benjamin RS, Patel S, Song J, Lazar AJ, Wang WL, Kurzrock R, Pappo A, Anderson PM, Schwartz GK, Araujo D, Cuglievan B, Ratan R, McCall D,...
Wed Jul 08, 2020 13:50
Related Articles Immunoglobulin M Paraproteinaemias. Cancers (Basel). 2020 Jun 25;12(6): Authors: Girard LP, Soekojo CY, Ooi M, Poon LM, Chng WJ, de Mel S Abstract Monoclonal paraproteinaemia is an increasingly common reason for referral to haematology services. Paraproteinaemias may be associated with life-threatening haematologic malignancies but can also be an incidental finding requiring only observation. Immunoglobulin M (IgM) paraproteinaemias...
Wed Jul 08, 2020 13:50
Related Articles Bispecific Targeting of EGFR and Urokinase Receptor (uPAR) Using Ligand-Targeted Toxins in Solid Tumors. Biomolecules. 2020 Jun 25;10(6): Authors: Oh F, Modiano JF, Bachanova V, Vallera DA Abstract Ligand-targeted toxins (LTTs) are bioengineered molecules which are composed of a targeting component linked to a toxin that induces cell death once the LTT binds its target. Bispecific targeting allows for the simultaneous targeting...
Wed Jul 08, 2020 13:50
Related Articles LncRNA NEAT1 in Paraspeckles: A Structural Scaffold for Cellular DNA Damage Response Systems? Noncoding RNA. 2020 Jul 01;6(3): Authors: Taiana E, Ronchetti D, Todoerti K, Nobili L, Tassone P, Amodio N, Neri A Abstract Nuclear paraspeckle assembly transcript 1 (NEAT1) is a long non-coding RNA (lncRNA) reported to be frequently deregulated in various types of cancers and neurodegenerative processes. NEAT1 is an indispensable structural...
Wed Jul 08, 2020 13:50
Immune Checkpoint Inhibitors in the Treatment of Renal Cancer: Current State and Future Perspective.
Related Articles Immune Checkpoint Inhibitors in the Treatment of Renal Cancer: Current State and Future Perspective. Int J Mol Sci. 2020 Jun 30;21(13): Authors: Lavacchi D, Pellegrini E, Palmieri VE, Doni L, Mela MM, Di Maida F, Amedei A, Pillozzi S, Carini M, Antonuzzo L Abstract Systemic treatment of renal cancer (RCC) has undergone remarkable changes over the past 20 years with the introduction of immunotherapeutic agents targeting programmed...
Wed Jul 08, 2020 13:50
Related Articles The current role of BTK inhibitors in the treatment of Waldenstrom's Macroglobulinemia. Expert Rev Anticancer Ther. 2020 Jul 07;: Authors: Gavriatopoulou M, Fotiou D, Ntanasis-Stathopoulos I, Dimopoulos MA Abstract INTRODUCTION: Waldenstrom's Macroglobulinemia (WM) is a rare, indolent lymphoplasmacytic lymphoma characterized by heterogeneous clinical and genomic profile. Bruton's tyrosine kinase (BTK) is central to the signaling...
Wed Jul 08, 2020 13:50
Publication date: Available online 6 July 2020Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Eliane F. Souza, Jéssica A.R. Ambrósio, Bruna C.S. Pinto, Milton Beltrame, Kumiko K. Sakane, Juliana G. Pinto, Juliana Ferreira-Strixino, Erika P. Gonçalves, Andreza R. Simioni
Wed Jul 08, 2020 13:48
Publication date: Available online 6 July 2020Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Gabriel Garcia de Carvalho, Julio Cesar Sanchez-Puetate, Maria Carolina Donatoni, Patricia Milagros Maquera Huacho, Alessandra Nara de Souza Rastelli, Kleber Thiago de Oliveira, Denise Madalena Palomari Spolidorio, Daniela Leal Zandim-Barcelos
Wed Jul 08, 2020 13:48
Publication date: Available online 6 July 2020Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Paul J. Shim, Nathalie C. Zeitouni
Wed Jul 08, 2020 13:48
Publication date: Available online 6 July 2020Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Luke J. McLellan, Marco Morelli, Emilio Simeone, Marina Khazova, Sally H. Ibbotson, Ewan Eadie
Wed Jul 08, 2020 13:48
The history of animal evolution, and the relative placement of extant animal phyla in this history is, in principle, testable from phylogenies derived from molecular sequence data. Though datasets have increased in size and quality in the past years, the contribution of individual genes (and ultimately amino acid sites) to the final phylogeny is unequal across genes. Here we demonstrate that removing a small fraction of sites strongly favoring one topology can produce a highly-supported tree of an...
Wed Jul 08, 2020 03:00
Background Introduced predators at seabird colonies and parasites may have lethal and/or sub-lethal consequences for bird populations. We assessed the potential sub-lethal negative effects of these stressors in a native seabird listed as vulnerable in its south-eastern pacific distribution. This study was conducted in two red-tailed tropicbird (Phaethon rubricauda) colonies, one located in Rapa Nui Island, which is threatened by the presence of introduced predators, and the other located in Salas...
Wed Jul 08, 2020 03:00
Only a few bird species are known to produce low-frequency vocalizations. We analyzed the display vocalizations of Western Capercaillie males kept in breeding centers and identified harmonically structured signals with a fundamental frequency of 28.7 ± 1.2 Hz (25.6–31.6 Hz). These low-frequency components temporally overlap with the Whetting phase (96% of its duration) and they significantly contribute to the distinct vocal expression between individuals. The resulting model of discrimination analysis...
Wed Jul 08, 2020 03:00
The life cycle of intracellular RNA mainly involves transcriptional production, splicing maturation and degradation processes. Their dynamic changes are termed as RNA life cycle dynamics (RLCD). It is still challenging for the accurate and robust identification of RLCD under unknow the functional form of RLCD. By using the pulse model, we developed an R package named pulseTD to identify RLCD by integrating 4sU-seq and RNA-seq data, and it provides flexible functions to capture continuous changes...
Wed Jul 08, 2020 03:00
Miocene terrestrial mammals are poorly known from the Atlantic Coastal Plain. Fossils of the Order Carnivora from this time and region are especially rare. We describe a carnivoran mandible with a p4 from the late Oligocene or early early Miocene Belgrade Formation in Jones County, North Carolina. Comparisons are made with carnivoran jaws with similar premolar and molar lengths from the late Oligocene and Miocene of North America and Eurasia. These indicate that the North Carolina jaw is assignable...
Wed Jul 08, 2020 03:00
This study pointed to explore if variations in circulating levels of metabolites in the blood stream of no. 25 feral donkeys occur in view of the different coat color between specimens of Asinara (albino, no. 8) vs. Sardo (dun-grey, no. 17) breed. All individuals involved in this investigation are living in the nature, at Mediterranean latitudes and roam in the same areas all over the National Park of Capo Caccia, where they feed on spontaneous vegetation sources. The study was conducted during the...
Wed Jul 08, 2020 03:00
The implementation of policies promoting the adoption of an open science (OS) culture must be accompanied by indicators that allow monitoring the uptake of such policies and their potential effects on research publishing and sharing practices. This study presents indicators of open access (OA) at the institutional level for universities worldwide. By combining data from Web of Science, Unpaywall and the Leiden Ranking disambiguation of institutions, we track OA coverage of universities’ output for...
Wed Jul 08, 2020 03:00
Studies of soft tissue, cells and original biomolecular constituents preserved in fossil vertebrates have increased greatly in recent years. Here we report preservation of ‘skin’ with chemical and molecular characterization from a three-dimensionally preserved caudal portion of an aspidorhynchid Cretaceous fish from the equatorial Barremian of Colombia, increasing the number of localities for which exceptional preservation is known. We applied several analytical techniques including SEM-EDS, FTIR...
Wed Jul 08, 2020 03:00
Individuals with knee joint pathologies exhibit quadriceps dysfunction that, during walking, manifests as smaller peak knee extensor moment (pKEM) and reduced knee flexion excursion. These changes persist despite muscle strengthening and may alter stance phase knee joint loading considered relevant to osteoarthritis risk. Novel rehabilitation strategies that more directly augment quadriceps mechanical output during functional movements are needed to reduce this risk. As an important first step, we...
Wed Jul 08, 2020 03:00
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