Related Articles [Effect of disulfiram on epithelial-mesenchymal transformation of oral squamous cell carcinoma cells]. Shanghai Kou Qiang Yi Xue. 2020 Apr;29(2):138-145 Authors: Wang XM, Jiang Y Abstract PURPOSE: To investigate the effect of disulfiram on epithelial-mesenchymal transformation(EMT) in oral squamous cell carcinoma(OSCC) cells based on Smad4 mutation. METHODS: The cancer tissues and adjacent normal tissues of 46...
Wed Jul 08, 2020 13:12
Related Articles Isolation and Analysis of Tumor-Derived Exosomes. Curr Protoc Immunol. 2019 12;127(1):e91 Authors: Ludwig N, Hong CS, Ludwig S, Azambuja JH, Sharma P, Theodoraki MN, Whiteside TL Abstract A method for isolation of exosomes from tumor cell supernatants or cancer patients' plasma is presented. Tumor-derived exosomes (TEX) are defined as a subset of extracellular vesicles (EVs) sized at 30 to 150 nm and originating from multivesicular...
Wed Jul 08, 2020 13:12
Related Articles Mohs Micrographic Surgery at the Skin and Cancer Foundation Australia, 20 Years Later (1997-2017). Dermatol Surg. 2020 02;46(2):165-168 Authors: Stewart TJ, Moreno Bonilla G, Venning VL, Lee S, Fernandez-Peñas P Abstract BACKGROUND: The availability of Mohs micrographic surgery (MMS) in Australia has increased dramatically since its inception in the 1980s. OBJECTIVE: This study aimed to describe the evolution of MMS...
Wed Jul 08, 2020 13:12
Related Articles The Pangenome: Diversity, Dynamics and Evolution of Genomes Book. 2020 Authors: Tettelin H, Medini D Abstract The stunning ability of bacteria to evolve and adapt has contributed to the success of these single cells, which have inhabited the Earth for billions of years and play vital roles in the environment and in human health. The goal of this chapter is to present and discuss the population-level organizational scheme of bacterial pangenomes,...
Wed Jul 08, 2020 14:40
Tenosynovial giant cell tumor of the suboccipital region - A rare, benign neoplasm in this location.
Related Articles Tenosynovial giant cell tumor of the suboccipital region - A rare, benign neoplasm in this location. J Clin Neurosci. 2020 Jul 03;: Authors: Singh R, Stienen MN, Ganjoo K, Kolahi KS, Cayrol R, Charville GW, Born DE, Zygourakis CC Abstract Tenosynovial giant cell tumors (TGCTs) are benign neoplasms that arise from the synovium of tendon sheaths, bursae, and joints. We report a rare presentation of TGCT involving the suboccipital...
Wed Jul 08, 2020 13:05
Related Articles Chemical, Physical and Biological Triggers of Evolutionary Conserved Bcl-xL-Mediated Apoptosis. Cancers (Basel). 2020 Jun 25;12(6): Authors: Ianevski A, Kulesskiy E, Krpina K, Lou G, Aman Y, Bugai A, Aasumets K, Akimov Y, Bulanova D, Gildemann K, Arutyunyan AF, Susova OY, Zhuze AL, Ji P, Wang W, Holien T, Bugge M, Zusinaite E, Oksenych V, Lysvand H, Gerhold JM, Bjørås M, Johansen P, Waage A, Heckman CA, Fang EF, Kainov DE Abstract ...
Wed Jul 08, 2020 13:05
Publication date: September 2020Source: World Neurosurgery, Volume 141Author(s): Jinbo Huang, Hailing Liu, Hai Chen, Li Yuan, Ling Fang, Zhi Yang
Wed Jul 08, 2020 12:59
Publication date: September 2020Source: World Neurosurgery, Volume 141Author(s): Kamran Aghayev
Wed Jul 08, 2020 12:59
Publication date: September 2020Source: World Neurosurgery, Volume 141Author(s): Shih-Shan Lang, William Paden, Andrew P. Steenhoff, Kevin Hines, Phillip B. Storm, Jimmy Huh
Wed Jul 08, 2020 12:59
Publication date: September 2020Source: World Neurosurgery, Volume 141Author(s): Daisuke Sato, Hirokazu Takami, Yu Teranishi, Osamu Ishikawa, Nobuhito Saito
Wed Jul 08, 2020 12:59
Publication date: September 2020Source: World Neurosurgery, Volume 141Author(s): Fumiaki Fujihara, Toyohiko Isu, Kyongsong Kim, Kimiya Sakamoto, Juntaro Matsumoto, Koichi Miki, Masaki Ito, Masanori Isobe, Tooru Inoue
Wed Jul 08, 2020 12:59
Publication date: September 2020Source: World Neurosurgery, Volume 141Author(s): Hatham Alkanhal, Kumar Das, Harish Poptani
Wed Jul 08, 2020 12:59
Publication date: Available online 8 July 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Max Sallis Osborne, Emma Hoskison, Anne Child-Hymas, Jaspreet Gill, Ann Louise McDermott
Wed Jul 08, 2020 12:46
Abstract All gibbon species (Family: Hylobatidae ) are considered threatened with extinction and recognized on the International Union for Conservation of Nature Red List of Threatened Species. Because gibbons are one of the most threatened families of primates, monitoring their status is now critically important. Long‐term monitoring programs applying occupancy approaches, in addition to assessing occurrence probability, improves understanding of other population parameters such as site...
Tue Jul 07, 2020 11:04
Publication date: Available online 7 July 2020Source: Ultrasound in Medicine & BiologyAuthor(s): Holger Rüger, Georgios Psychogios, Monika Jering, Johannes Zenk
Wed Jul 08, 2020 12:40
Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. Background:T-cell acute lymphoblastic leukemia is a hematologic malignancy characterized by T-cell proliferation, and in many cases, the ectopic expression of the oncogenic transcription factor T-cell acute lymphocytic leukemia protein 1 (TAL1). MicroRNA-7 has been shown to play a critical role in proliferation, migration, and treatment sensitivity in a diverse array of cancers. In this study, we sought to establish...
Tue Jul 07, 2020 12:42
Publication date: Available online 8 July 2020Source: Clinical NeurophysiologyAuthor(s): Antonello Grippo, Aldo Amantini
Wed Jul 08, 2020 12:25
Publication date: Available online 8 July 2020Source: Clinical NeurophysiologyAuthor(s): Katherine A. Zarroli, Ramon Edmundo D. Bautista
Wed Jul 08, 2020 12:25
Abstract Background There are fundamental similarities and differences between the jaw and hand motor systems. However, it is unclear how the two systems respond to unpredictable task demands. Objective To investigate and compare the force control of the jaw motor system (OMS) and the hand motor system (HMS) during unpredictable load changes. Methods Seventeen healthy adults (24.0 ± 4.3 years) performed two standardized force control tasks (OMS and HMS). During the OMS, the participants...
Tue Jul 07, 2020 20:18
Abstract Background Alteration in tongue mobility requires rehabilitation work through oral motor exercises. These exercises can be integrated with computer games to increase the patient’s motivation during treatment. Objective To investigate the influence of tongue mobility on children’s motor performance in a computer game reliant on lingual movements. Methods A cross‐sectional descriptive observational study was carried out with 16 children with altered tongue mobility and 16 children...
Tue Jul 07, 2020 15:09
Abstract Background The efficacy of oral appliance (OA) varies greatly in patients with obstructive sleep apnea (OSA). Objectives The purpose of this cross‐sectional study was to investigate the success rate of OA for OSA patients. Methods This study was based on a cross‐sectional multicenter survey of OA therapy for the management of OSA called the JAMS (Japanese Cross‐sectional Multicenter Survey) Study performed at 10 medical institutions. A total of 442 patients fulfilled the...
Tue Jul 07, 2020 11:45
Tue Jul 07, 2020 13:09
Tue Jul 07, 2020 11:38
Cholangiocarcinoma is a malignant neoplasm originating from the biliary epithelium. Its incidence is highest in Southeast Asia, especially in Thailand. Mucinous intrahepatic cholangiocarcinoma (mucinous iCCA), characterized by an abundant extracellular mucin pool accounting for at least 50% of total tumor volume, is an extremely rare variant of such malignancy and is notorious for rapid progression and dismal prognosis. We conducted an 11‐year retrospective analysis of resected mucinous iCCAs from...
Tue Jul 07, 2020 20:29
Pulmonary tumor thrombotic microangiopathy (PTTM) is histologically characterized by micro tumor cell embolism and intimal fibrocellular proliferation of pulmonary arteries or arterioles. We report a secondary case of PTTM associated with extramammary Paget's disease (EMPD). The patient was a 72‐year‐old man with exertional dyspnea. Clinical examinations found he had pulmonary hypertension and multiple osteolytic lesions of vertebra. Cytological analysis of pulmonary wedge artery sample detected...
Tue Jul 07, 2020 20:27
Tue Jul 07, 2020 20:27
Key points Gamma oscillations (30–80 Hz) are important for cognitive functions and depend on the synchronized activity of fast‐spiking interneurons (FSN), which is crucial for network stability. Gamma oscillations are degraded in Alzheimer's disease (AD) patients exhibiting cognitive impairment, with the degree of cognitive decline correlating with the severity of gamma disruption in response to neurotoxic amyloid‐beta peptide (Aβ). Small molecule compounds EX15 and RE01 modulate Kv3.1/Kv3.2...
Tue Jul 07, 2020 21:09
Background The ability to reconstruct large cranial base defects has greatly improved with the development of pedicled vascularized flaps. The temporoparietal fascia flap (TPFF) is a viable alternative to the Hadad‐Bassagasteguy nasoseptal flap for large ventral skull‐base defects. This study aims to characterize the size of the TPFF necessary for optimal ventral skull‐base reconstruction. Methods Eleven formaldehyde‐fixed cadaveric heads were used to harvest TPFF of varying heights on each...
Tue Jul 07, 2020 21:34
Background Nonallergic rhinitis (NAR) is currently a diagnosis of exclusion with an unclear pathophysiologic mechanism and limited treatment options. In patients diagnosed with NAR based on symptoms, negative skin testing and positive optical rhinometry (ORM), the study's objective was to evaluate the therapeutic action of intranasal capsaicin in the management of rhinitic symptoms and the effect on ORM readings. Methods Patients with a history of NAR underwent screening by a diagnostic intranasal...
Tue Jul 07, 2020 21:10
Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common heterogenous disease in the patients with chronic airway diseases. This study investigated the role of blood eosinophil count (BEC) in the classification of CRSwNP and its recurrence in eosinophilic CRSwNP. Methods Sixty‐five patients who underwent nasal endoscopic resection of CRSwNP were recruited and divided into eosinophilic CRSwNP and non‐eosinophilic CRSwNP groups based on the levels (10% cutoff) of eosinophil infiltration...
Tue Jul 07, 2020 20:45
Tue Jul 07, 2020 20:44
Abstract COVID19 became pandemic since this is a disease with a high infection rate. The study's object is to identify clinical and histopathological findings of cutaneous manifestations of COVID19 patients. The evidence was analyzed in PubMed, CINAHL, Cochrane, Web of Science and Scopus, with the search strategy (covid 19 OR covid‐19 OR corona OR coronavirus OR sars‐cov‐2) AND (cutaneous or cutaneous manifestations OR), and 17 studies were included, involving 351 cases with COVID19 and skin manifestations....
Tue Jul 07, 2020 22:58
Abstract Filler injections have become exceedingly popular in the last decade, and injectors across the globe are using them for facial contouring and reversing the age‐related changes. Thorough knowledge about the anatomy of important vessels and tissue planes is essential for injectors. During filler injections, injectors generally tend to pinch or pull the tissues with the non‐dominant hand for the ease of the procedure. These deformational forces lead to some changes in the anatomy of tissue...
Tue Jul 07, 2020 17:18
Abstract Dupilumab and cyclosporin are recommended treatments for moderate‐to‐severe atopic dermatitis (AD). The objective of this study was to investigate drug survival of dupilumab in comparison with CsA, reasons of drug discontinuation, and predictive parameters of drug survival in daily practice. Retrospective study including patients with moderate‐to‐severe AD treated with dupilumab or cyclosporin (CsA) from January 1, 2019 to April 30, 2020. Drug survival analysis was performed using the Kaplan‐Meier...
Tue Jul 07, 2020 13:45
Abstract Rosacea is a common inflammatory skin disease characterized by erythema, episodes of flushing and inflammatory lesions. It typically affects the face and is more prevalent among fair skin individuals affecting women more than men. Various treatments are available for rosacea with light‐based therapies commonly used in the management of erythema. The use of intradermal botulinum toxin type‐A has been reported to be beneficial in the treatment of rosacea‐associated erythema and flushing...
Tue Jul 07, 2020 13:44
Tue Jul 07, 2020 13:43
Abstract Psychodermatology addresses the connection between mind and skin. Psychodermatological disorders are mainly classified in to three major groups. First group is called Psychophysiologic disorders which are characterized by exacerbation or flare ups in skin lesion secondary to stress; primary psychiatric disorders is another group where no recognizable skin conditions present but all skin lesions are either self‐inflicted, delusional or obsessive in nature. Secondary psychiatric disorders...
Tue Jul 07, 2020 13:40
Abstract Background Various laser therapies have been used for the treatment of alopecia areata (AA). Enhanced hair regrowth was reported with the use of ablative fractional 2940‐nm erbium:yttrium‐aluminum‐garnet (Er:YAG) laser in a murine model. However, clinical effectiveness of fractional Er:YAG laser for hair disorders has not been investigated in human studies. The aim of our study was to assess effectiveness of 2940 nm fractional Er:YAG laser in the treatment of chronic AA that is unresponsive...
Tue Jul 07, 2020 13:39
Speech prosody has been applied in numerous speech emotion recognition tasks. Yet, especially in forensic speech science, a need for acoustic-phonetic analyses with human evaluation still exists since many current speech emotion models are trained with speech data wherein emotions are considered as constant states and the dynamic effects of the interlocutor have been disregarded; for instance, during an emergency call, the caller’s emotional prosody varies according to the communication with the...
Wed Jul 08, 2020 11:40
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