ABSTRACT Malignant peripheral nerve sheath tumor (MPNST) often does not respond well to chemotherapy and develops against a background of NF1. The purpose of this study was to examine the efficacy of pazopanib against MPNST. This study was designed as a physician‐initiated phase II clinical trial in patients with advanced MPNST. Patients were registered from 11 large hospitals. The primary endpoint was set to clarify the clinical benefit rate (CBR) at 12 weeks according to Response Evaluation Criteria...
Tue Jul 07, 2020 20:56
Abstract The sterile alpha motif and histidine‐aspartic domain‐containing protein 1 (SAMHD1) has been demonstrated to predict the response to high‐dose cytarabine consolidation treatment in acute myeloid leukemia patients. Here, we evaluated SAMHD1 as potential biomarker for the response to high‐dose cytarabine in mantle cell lymphoma (MCL) patients. We quantified SAMHD1 protein expression and determined the mutation status in patients of the MCL Younger and Elderly trials (n = 189), who had received...
Tue Jul 07, 2020 20:56
Abstract RAS, TP53 (p53) and MYC are amongst the most frequently altered driver genes in cancer. Thus, RAS is the most frequently mutated oncogene, MYC the most frequently amplified gene and TP53 the most frequently mutated tumour suppressor gene and overall the most frequently mutated gene in cancer. Theoretically, therefore, these genes are highly attractive targets for cancer treatment. However, as the protein products of each of these genes lack an accessible hydrophobic pocket into which low...
Tue Jul 07, 2020 20:55
Abstract The age‐standardised incidence of cervical cancer in Europe varies widely (between 3 and 25/100000 women‐years) in 2018. HPV vaccine coverage is low in countries with the highest incidence and screening performance is heterogeneous among European countries. A broad group of delegates of scientific professional societies and cancer organisations endorse the principles of the WHO call to eliminate cervical cancer as a public health problem, also in Europe. All European nations should, by...
Tue Jul 07, 2020 20:55
Abstract The risk of vulvar squamous cell carcinoma (VSCC) in patients with high‐grade vulvar intraepithelial neoplasia (VIN) is considered lower in high‐grade squamous intraepithelial lesion (HSIL) compared to differentiated VIN (dVIN), but studies are limited. This study investigated both the incidence of high‐grade VIN and the cumulative incidence of VSCC in patients with HSIL and dVIN separately. A database of women diagnosed with high‐grade VIN between 1991 and 2011 was constructed with data...
Tue Jul 07, 2020 20:55
ABSTRACT Evidence from animal models suggests that dietary fatty acids have both anticancer and tumor‐promoting effects. Whether dietary fatty acids are associated with colorectal cancer (CRC) in humans remains inconclusive. We investigated associations between dietary fatty acids and risk of CRC among 59,986 men who participated in the Shanghai Men's Health Study (SMHS), an ongoing population‐based prospective cohort study. We identified 876 incident CRC cases in the SMHS during a mean follow‐up...
Tue Jul 07, 2020 20:53
Abstract The influence of polyunsaturated fatty acids (PUFAs) on risk of colorectal cancer precursors remains largely unknown. We examined the associations of erythrocyte PUFAs, including n‐3 and n‐6 PUFAs, with risk of colorectal conventional adenomas and serrated polyps in 4517 participants from three U.S. prospective cohorts who had provided a blood sample and undergone at least one endoscopic exam. We calculated the multivariable odds ratios (ORs) per 1‐standard deviation increment in individual...
Tue Jul 07, 2020 20:52
ABSTRACT Laryngeal squamous cell carcinoma (LSCC) is a highly malignant tumor originated from respiratory system. Although there have been many improvements in therapy until now, reducing the high mortality is still difficult. Understanding the cellular heterogeneity of LSCC could contribute to improve this problem. Single‐cell RNA sequencing (scRNA‐seq) was applied to dissect the cell composition and molecular characteristics of LSCC tissues. Immunohistochemistry (IHC) staining of the LSCC tissues...
Tue Jul 07, 2020 20:52
Abstract At present, mostly case‐control and retrospective studies have investigated the association between etiologic risk factors and the development of histologic subtypes of renal cell carcinoma (RCC). Therefore, we assessed the heterogeneity between body mass index (BMI), cigarette smoking, alcohol consumption and hypertension across clear‐cell RCC (ccRCC) and papillary RCC (pRCC) risk in the prospective Netherlands Cohort Study on diet and cancer (NLCS).In 1986, 120,852 participants aged 55‐69...
Tue Jul 07, 2020 20:52
ABSTRACT Increasing numbers of common genetic variants associated with colorectal cancer (CRC) have been identified. This study aimed to determine whether risk prediction based on common genetic variants might enable stratification for CRC risk. Meta‐analysis of eleven genome‐wide association studies (GWAS) comprising 16,871 cases and 26,328 controls was performed to capture CRC susceptibility variants. Genetic prediction models with several candidate polygenic risk scores (PRSs) were generated...
Tue Jul 07, 2020 20:51
Abstract Background Non‐alcoholic fatty liver disease (NAFLD) is linked to a raised risk of cardiovascular diseases (CVD), although the underlying mechanisms are not completely known. A reduced myocardial mechano‐energetic efficiency (MEE) has been found to be an independent predictor of CVD. Objective To evaluate the association between NAFLD and a compromised MEE. Methods Myocardial MEE was assessed by a validated echocardiography‐derived measure in 699 non‐diabetic...
Tue Jul 07, 2020 17:46
Abstract Introduction The gut microbiome may contribute to the development of obesity. So far, the extent of microbiome variation in people with obesity has not been determined in large cohorts and for a wide range of body mass index (BMI). Here, we aimed to investigate whether the faecal microbial metagenome can explain the variance in several clinical phenotypes associated with morbid obesity. Methods Caucasian subjects were recruited at our hospital. Blood pressure and...
Tue Jul 07, 2020 11:54
Abstract Background & Aims The progression of nonalcoholic fatty liver disease (NAFLD) into severe histological forms (steatohepatitis‐NASH) is paralleled by the occurrence of complex molecular processes. Mitochondrial dysfunction is a hallmark feature of advanced disease. Mitochondrially‐encoded cytochrome B (cytochrome b, MT‐CYB )—a member of the oxidative phosphorylation system, is a key component of the respirasome supercomplex. Here, we hypothesized that NAFLD severity...
Tue Jul 07, 2020 11:36
Abstract Background Fine needle aspiration cytology is an important diagnostic tool in salivary gland cytopathology. However, cytology of salivary gland neoplasms shows diversity with morphological overlap, heterogeneity and subjective variability, posing diagnostic challenge. Nuclear cytomorphometric image analysis turns the subjective criteria into quantitative parameters, which may aid not only in differentiating between benign and malignant tumours but also can aid in categorising challenging...
Tue Jul 07, 2020 19:02
Abstract Fine‐needle aspiration biopsy (FNAB) has been used for many decades in the investigation of breast lesions. Originally, cases were signed out using the categories benign and malignant. The benign category contained specimens showing fibrocystic change as well as benign neoplasms such as fibroadenoma. The malignant category contained carcinomas, lymphomas, and phyllodes tumors with specific diagnoses often given in place of the term malignant. Categorization was less clear when the cytopathologists...
Tue Jul 07, 2020 16:24
Background and Objectives Patients around the world use a lancing device to perform self‐monitoring of blood sugar (SMBG). However, there are always fears of needles and pain. Therefore, less painful devices are being developed. The purpose of this study was to compare the usefulness and safety of a laser lancing device (without a needle) to a conventional needle lancet (with a needle) for capillary blood sampling. Study Design/Materials and Methods A total of 40 healthy subjects were enrolled...
Tue Jul 07, 2020 21:34
Background and Objectives To compare temporal rates of debris removal from an artificial root canal for three laser‐assisted irrigation modalities single‐pulse super short pulse (SSP), and two dual‐pulse X‐SWEEPS and AutoSWEEPS, and for two fiber‐tip (FT) geometries flat and radial, and to evaluate the dependence of the debris flushing rate on the delay between the SWEEPS laser pulse pair. Study Design/Materials and Methods Laser‐assisted irrigation was performed with a pulsed Er:YAG laser...
Tue Jul 07, 2020 15:43
Objectives: Tinnitus is the perception of sound in ears or head without corresponding external stimulus. Despite the great amount of literature concerning tinnitus treatment, there are still no evidence-based established treatments for curing or for effectively reducing tinnitus intensity. Sham-controlled studies revealed beneficial effects using repetitive transcranial magnetic stimulation (rTMS). Still, results show moderate, temporary improvement and high individual variability. Subcallosal...
Thu Jul 02, 2020 03:00
Objectives: To conduct a systematic review to address two research questions: (Q1) Does hearing loss have an effect on fatigue? (Q2) Does hearing device fitting have an effect on fatigue? It was hypothesized that hearing loss would increase fatigue (H1), and hearing device fitting would reduce fatigue (H2). Design: Systematic searches were undertaken of five bibliographic databases: Embase, MedLine, Web of Science, Psychinfo, and the Cochrane Library. English language peer-reviewed...
Thu Jul 02, 2020 03:00
Abstract Purpose Gitelman syndrome (GS) is an autosomal recessive renal tubular disease that arises as a consequence of mutations in the SLC12A3 gene, which codes for an Na–Cl cotransporter (NCC) in distal renal tubules. This study was designed to explore the mutations associated with GS in an effort to more fully understand the molecular mechanisms governing GS. Methods...
Wed Jul 08, 2020 03:00
Background: In cases of intractable epilepsy resistant to drug therapy, hemispherectomy is often the only treatment option to mitigate seizures; however, the true long-term subjective visual outcomes are relatively unexplored. In this study, we sought to determine and characterize patient-reported visual function years after hemispherectomy. Methods: This was an observational study conducted on a large cohort of children with seizure disorder treated with cerebral hemispherectomy. An...
Tue Jul 07, 2020 03:00
No abstract available
Tue Jul 07, 2020 03:00
Background: During the COVID-19 pandemic tele-health modalities have come to prominence as a strategy for providing patient care when in-person care provision opportunities are limited. The degree of adoption by neuro-ophthalmologists has not been quantified. Methods: Telehealth utilization pre- and peri-COVID-19 was surveyed among practicing neuro-ophthalmologists in and outside the US using an on-line platform. Demographics, perceived benefits, barriers, and utility for different...
Tue Jul 07, 2020 03:00
No abstract available
Tue Jul 07, 2020 03:00
No abstract available
Thu Jul 02, 2020 03:00
Background: COVID-19, known as the “coronavirus”, has spread to over 170 countries. In response, many organizations have spoken out and called to cancel all elective surgical procedures. Objective: Our study aimed to provide clear recommendations for plastic surgeons to follow by addressing the following issues: 1) What defines elective surgery, and where does one draw the line between essential versus nonessential services? 2) How does this differ in the hospital versus private practice setting?...
Thu Jul 02, 2020 03:00
No abstract available
Thu Jul 02, 2020 03:00
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Thu Jul 02, 2020 03:00
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Thu Jul 02, 2020 03:00
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Thu Jul 02, 2020 03:00
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Thu Jul 02, 2020 03:00
The practice of plastic surgery has become more complex. As plastic surgeons face the post-graduate realities of contracts, negotiations, and health system employment, they are frequently unprepared to effectively manage these challenges. Further, many plastic surgery training programs do not emphasize real-world business and policy concerns in residency training. Plastic and Reconstructive Surgery endeavors to provide robust conceptual education and guidance in business and policy in order to help...
Thu Jul 02, 2020 03:00
No abstract available
Thu Jul 02, 2020 03:00
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Thu Jul 02, 2020 03:00
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Thu Jul 02, 2020 03:00
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Thu Jul 02, 2020 03:00
Background: The utility of dermal regeneration templates for treating high-risk diabetic foot wounds (DFW) is unclear. We report wound healing and major amputation outcomes among a cohort of diabetic patients with complex DFW treated in a multidisciplinary setting. Methods: All patients with complex DFW treated with a dermal regeneration template (03/2013-2/2019) were captured in a prospective institutional database. DFW severity was classified according to the Society for Vascular Surgery...
Thu Jul 02, 2020 03:00
No abstract available
Thu Jul 02, 2020 03:00
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Thu Jul 02, 2020 03:00
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Thu Jul 02, 2020 03:00
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Thu Jul 02, 2020 03:00
No abstract available
Thu Jul 02, 2020 03:00
Abstract Empathy for pain is at the basis of altruistic behaviors and is known to be modulated by variables such as group membership, pleasantness or unpleasantness of situations and social relationships. Also, face attractiveness and aesthetic judgment might play a role when observing a person in painful conditions, by increasing individuals’ empathic responsiveness. Indeed, physical attractiveness can modify both the perception of the face itself and its reception in a social...
Wed Jul 08, 2020 03:00
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