Abstract We present the operative procedure of transoral robotic selective neck dissection for papillary thyroid carcinoma. A 28‐year‐old woman, diagnosed with papillary thyroid carcinoma and lymph node metastasis at right level IV, underwent total thyroidectomy, central neck dissection, and selective neck dissection involving levels III and IV via the transoral robotic approach. A 1.5‐2‐cm central incision was made near the base of the lower lip frenulum, and two lateral incisions were made close...
Tue Jul 07, 2020 22:48
Abstract Background There is a well documented racial disparity in overall survival for oropharyngeal squamous cell carcinoma (OPSCC); however, it is unknown to what extent this disparity varies by HPV‐status. Methods A literature search was conducted through December 2019 using Ovid Medline, Cochrane Library, Embase, Scopus, and Clinicaltrials.gov. PRISMA guidelines were followed. A meta‐analysis was conducted using random effects models to obtain pooled hazard ratios (HRs). Results...
Tue Jul 07, 2020 22:30
Abstract Background PERP (p53 apoptosis effector related to PMP22) localizes to desmosomes and suppresses squamous cell carcinoma development. Loss of PERP leads to worse local control in head and neck squamous cell carcinoma (HNSCC), likely by destabilizing desmosomes. We evaluated PERP loss at HNSCC surgical margins as a predictor of local relapse. Methods Combining discovery (n = 17) and validation (n = 31) cohorts, we examined membranous PERP protein expression by immunohistochemistry...
Tue Jul 07, 2020 22:29
Abstract Background Delays in postoperative radiotherapy (PORT) for head and neck cancer (HNC) increase the risk for recurrence and mortality. The multifactorial nature of delays calls for an in‐depth understanding of potential contributors from the patient's and provider's perspectives. We sought to identify causes of delays in adjuvant radiotherapy initiation for HNC. Methods We performed a mixed‐methods study including patients with HNC care team members. Forty in‐depth interviews were...
Tue Jul 07, 2020 22:24
Abstract The EFSA Panel on Plant Health performed a pest categorisation of Helicoverpa zea (Lepidoptera: Noctuidae) (American cotton bollworm, corn earworm) for the EU . H. zea is a polyphagous species that feeds on over 100 plant species. The crops most frequently recorded as host plants are maize, sorghum, cotton, beans, peas, chickpeas, tomatoes, aubergines, peppers and, to a lesser extent, clover, okra, cabbages, lettuces, strawberries, tobacco, sunflowers, cucurbits and ornamentals. H. zea...
Tue Jul 07, 2020 14:33
Abstract The conclusions of the EFSA following the peer review of the initial risk assessments carried out by the competent authorities of the rapporteur Member State, Greece, and co‐rapporteur Member State, Germany, for the pesticide active substance clodinafop‐propargyl are reported. The context of the peer review was that required by Commission Implementing Regulation (EU ) No 844/2012. The conclusions were reached on the basis of the evaluation of the representative uses of clodinafop‐propargyl...
Tue Jul 07, 2020 13:01
Abstract The conclusions of EFSA following the peer review of the initial risk assessments carried out by the competent authority of the rapporteur Member State the Netherlands for the pesticide active substance Bacillus amyloliquefaciens strain AH 2 are reported. The context of the peer review was that required by Regulation (EC ) No 1107/2009 of the European Parliament and of the Council. The conclusions were reached on the basis of the evaluation of the representative use of Bacillus amyloliquefaciens...
Tue Jul 07, 2020 13:01
Abstract Following a request from the European Commission, the Panel on Plant Health performed a pest categorisation on tomato leaf curl New Delhi virus (ToLCNDV ). ToLCNDV is a well‐defined bipartite Begomovirus species, sometimes associated with satellite molecules. It is transmitted by Bemisia tabaci to a wide range of hosts. ToLCNDV is reported from Estonia, Greece, Italy, Portugal and Spain, with limited distribution. The prevalent strain (ToLCNDV ‐ES ) in these countries is particularly...
Tue Jul 07, 2020 13:01
Abstract The cellular and molecular mechanisms underlying leptin‐mediated brain protection against cerebral ischemia were investigated at the blood brain barrier (BBB) and neutrophil level. Through the ischemia/reperfusion (I/R) animal model, we found that leptin expression level was significantly decreased in ischemic hemisphere. Brain injection with leptin (15 μg/kg, intracisternally) could block the I/R‐increased BBB permeability, activation of matrix metallopeptidase 9 (MMP‐9) and brain infiltration...
Tue Jul 07, 2020 21:00
Journal of International Medical Research, Volume 48, Issue 7, July 2020. ObjectiveThere have been no recent improvements in the glioblastoma multiforme (GBM) outcome, with median survival remaining 15 months. Consequently, the need to identify novel biomarkers for GBM diagnosis and prognosis, and to develop targeted therapies is high. This study aimed to establish biomarkers for GBM pathogenesis and prognosis.MethodsIn total, 220 overlapping differentially expressed genes (DEGs) were obtained by...
Tue Jul 07, 2020 10:04
“Stem cell tourism,” the practice of offering unproven cellular preparations to patients as approved therapy, is rising in neurology. Currently, the experiences of patients and reported complications from these procedures are unknown in the US. We evaluate academic neurologists' experiences with stem cell tourism and assess perceived competency on discussing this topic with patients. We found a lack of neurologist preparedness to discuss stem cell therapies with patients and an alarming list of unreported...
Tue Jul 07, 2020 11:34
Abstract Cutaneous lupus erythematosus (CLE) is a heterogeneous autoimmune disease encompassing a broad spectrum of skin conditions including localized plaques or widespread lesions, which may be accompanied by systemic involvement (systemic lupus erythematosus (SLE)). The disease is characterized by necroptotic keratinocytes and a cytotoxic immune cell infiltrate at the dermo‐epidermal junction (DEJ), orchestrated by interferon (IFN)‐regulated proinflammatory cytokines. Molecular analyses revealed...
Tue Jul 07, 2020 15:34
Abstract Despite groundbreaking new treatments such as checkpoint inhibition and targeted therapy, the overall response and survival rates are limited in patients with metastatic melanoma. Here, we hypothesize that melatonin and its metabolites could be promising boosters of the efficacy of BRAF/MEK inhibitors in patients with advanced melanoma. Melatonin, a well‐known endogenous synchronizer of the circadian biorhythm has a variety of promising effects for melanoma biology. It regulates proliferation,...
Tue Jul 07, 2020 11:18
Abstract It has been observed that there is an inverse relationship between fiber size and oxidative capacity due to oxygen, ADP, and ATP diffusion limitations. We aimed to see if regular endurance exercise alongside a hypertrophic stimulus would lead to compromised adaptations to both, particularly in older animals. Here we investigated the effects of combining overload with regular endurance exercise in young (12 months) and old (26 months) male mice. The plantaris muscles of...
Wed Jul 08, 2020 03:00
Abstract Background The most common cause for epiphora is nasolacrimal duct obstruction (NLDO). Epiphora may decrease the quality of life due to recurrent lacrimal sac infections, worsening vision and distress in public environments. Patency of nasolacrimal duct can be verified by various clinical tests. However, there is no standardized questionnaire for symptom evaluation of NLDO patients. The objective of this study was to perform translation, cross‐cultural adaptation, and validation of the...
Tue Jul 07, 2020 20:31
Abstract Background Parent's history of atopic traits increases the risk of the same traits in their children, but mother's history may confer an increased risk compared to father's history. Objective To investigate parent‐specific effects on risk of developing allergic sensitization and asthma in childhood. Methods We included 685 parent‐child trios from the Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC2010) cohort. Parent's asthma was assessed by structured...
Tue Jul 07, 2020 19:01
Abstract Background Smoking worsens underlying asthma inflammation and also induces resistance to inhaled corticosteroids (ICS). Small airways dysfunction measured by impulse oscillometry (IOS) is associated with worse control. Objectives We investigated the effects on small airways of adding long acting beta‐agonist (LABA) alone or with long acting muscarinic antagonist (LAMA) to ICS in asthmatic smokers. Methods 16 current smokers were enrolled: mean age 44 yr, FEV1 84%, FEF25‐75...
Tue Jul 07, 2020 14:55
Abstract Attention biases toward unpleasant information are evident among children and adults with a history of abuse and have been identified as a potential pathway through which abused children develop psychopathology. Identifying whether a history of childhood abuse affects the time course of attention biases in adults is critical, as this may provide intervention targets. The present study examined the time course of attention bias during an emotion‐word Stroop task using event‐related potentials...
Tue Jul 07, 2020 17:45
For many years, Clar’s aromatic sextet theory has served as a qualitative method for assessing the aromatic character of polycyclic aromatic hydrocarbons. A new approach, based on the calculation of isotropic magnetic shielding (IMS) contour plots, is shown to provide a feature‐rich picture of aromaticity that is both quantitative yet still easily interpreted. Chemists are visual creatures who are adept at discerning reactivity and chemical behavior from molecular structures. To quote Roald Hoffman,...
Tue Jul 07, 2020 22:44
The defective iron–cobalt oxide nanosheet is developed into a highly efficient OER catalyst through modulating its electron structure by oxygen vacancy creation and sulfur atom modification. Pairing with CoP3/Ni2P, its current density can reach up to 406.0 mA cm−2 at 2.3 V, meeting well with the industrial water splitting requirement. Abstract The oxygen vacancies of defective iron–cobalt oxide (FeCoO x ‐Vo) nanosheets are modified by the homogeneously distributed sulfur (S) atoms....
Tue Jul 07, 2020 22:00
The exploitation of new materials for adsorptive separation of industrially important hydrocarbons is of great importance in both scientific research and petrochemical industry. Nonporous adaptive crystals (NACs) as a robust class of synthetic materials have drawn much attention during the past five years for their superior performance in adsorption and separation. Pillararenes are the main family of macrocyclic arenes used for NACs construction, where the structure–function relationship has been...
Tue Jul 07, 2020 21:14
Metal‐organic frameworks (MOFs) and covalent organic frameworks (COFs) attracted enormous attention in recent years. Recently, MOF@COF are emerging as hybrid architectures combining the unique features of the individual components to enable the generation of materials displaying novel physicochemical properties. Herein we report an unprecedented use of aza‐Diels‐Alder cycloaddition reaction as postsynthetic modification of MOF@COF‐LZU1, to generate aza‐MOFs@COFs hybrid porous materials with extended...
Tue Jul 07, 2020 20:44
Advances in zeolites research emerging from interdisciplinary efforts have opened new opportunities beyond conventional applications. Colloids drive much current research owing to their distinct collective behaviors , but so far, zeolite used as a colloidal building block to construct ordered superstructures remains unexplored. Here we show that self‐assembly of colloidal zeolite LTA superball (ZAS) by tilted angle sedimentation forms macroscopic films with micro‐mesoporosity and 3D long‐range...
Tue Jul 07, 2020 19:15
The self‐assembly of inorganic nanoparticles into well‐ordered structures in the absence of solvents is generally hindered by van der Waals forces, leading to random aggregates between them. To address the problem, we functionalized rigid rare earth (RE) nanoparticles with a layer of flexible polymers by electrostatic complexation. Consequently, an ordered and solvent‐free liquid crystal (LC) state of RE nanoparticles was realized. The RE nanomaterials including nanospheres, nanorods, nanodiscs,...
Tue Jul 07, 2020 19:15
The development and malignancy of cancer cells are closely related to the changes of epigenome. In this work, a mitochondria‐targeted rhenium(I) complex ( DFX‐Re3 ) integrating the clinical iron chelating agent deferasirox ( DFX ) has been designed. By relocating iron to mitochondria and changing the key metabolic species related to epigenetic modifications, DFX‐Re3 can elevate the methylation levels of histone, DNA and RNA. As a consequence, DFX‐Re3 affects the events related to apoptosis,...
Tue Jul 07, 2020 19:14
Singlet fission in organic semiconducting materials has attracted great attention for the potential application in photovoltaic devices as the exciton multiplication process effectively compensates for thermal energy losses. Research interests have been concentrated on identifying working mechanisms of coherent SF processes in crystalline solids as ultrafast SF is hailed for efficient multiexciton generation. However, as long lifetime of the intermediate state, multiexcitonic triplet pair, in amorphous...
Tue Jul 07, 2020 18:16
The first stereoselective, near‐equimolar, and metal‐free oxidative bioconjugation of amino acids and oligopeptides to aldehydes is presented. Based on a newly developed organocatalytic oxidative concept, the C‐terminal and side chain carboxylic acid functionalities of amino acids and oligopeptides are shown to couple in a stereoselective manner to α‐branched aldehydes catalyzed by a chiral primary amine and a quinone as oxidizing agent. The oxidative coupling generally proceeds in high yield. For...
Tue Jul 07, 2020 17:49
Au(III) complexes with N‐Heterocyclic Carbenes (NHCs) ligands have shown remarkable potential as anticancer agents, yet their fate in vivo has not been thoroughly examined and understood. Herein we report on the synthesis of new Au(III)‐NHC complexes via direct oxidation with radioactive [ 124 I]I 2 as a valuable strategy to monitor the in vivo biodistribution of this class of compounds using positron emission tomography (PET). While, in vitro analyses provide direct evidence for the importance...
Tue Jul 07, 2020 17:48
Catalytic enantioselective α‐fluorination reactions of carbonyl compounds are among the most powerful and efficient synthetic methods for constructing optically active α‐fluorinated carbonyl compounds. Nevertheless, α‐fluorination of α‐nonbranched carboxylic acid derivatives is still a big challenge because of relatively high p K a values of their α‐hydrogen atoms and difficulty of subsequent synthetic transformation without epimerization. Here we show that chiral Cu(II)–3‐(2‐naphthyl)‐ L...
Tue Jul 07, 2020 17:47
Ultralong organic phosphorescence (UOP) has attracted increasing attention due to its potential applications in optoelectronics, bioelectronics, and security protection. However, achieving UOP with high quantum efficiency (QE) over 20% is still full of challenges due to the forbidden intersystem crossing (ISC) and fast non‐radiative transitions in organic molecules. Here, we present a novel strategy to enhance the QE of UOP materials by modulating intramolecular halogen bonding via structural isomerism....
Tue Jul 07, 2020 17:45
Despite the exceptionally high energy density of lithium metal anodes, the practical application of lithium metal batteries (LMBs) is still impeded by the instability of the interphase between the lithium metal and the electrolyte. To formulate a functional electrolyte system that can stabilize the lithium metal anode, one must understand the solvation behavior of the solvent molecules since the electrochemical properties of a solvent can be heavily influenced by its solvation status. We unambiguously...
Tue Jul 07, 2020 16:48
Aqueous Zn batteries are promising energy‐storage device due to low cost and high energy density. However, their lifespan is limited by irreversible Zn anodes due to water decomposition and Zn dendrite growth. Here, we separate aqueous electrolyte from Zn anode by coating a thin metal–organic framework (MOF) layer on anode and filling the pores of MOF with hydrophobic Zn(TFSI)2‐tris(2,2,2‐trifluoroethyl)phosphate (TFEP) organic electrolyte that is immiscible with aqueous Zn(TFSI)2‐H2O bulk electrolyte....
Tue Jul 07, 2020 16:46
Photo/electrocatalysis of water (H 2 O) splitting and CO 2 reduction reactions is known as the promising means to alleviate the energy crisis and excessive CO 2 emissions. For the hydrogen evolution reaction (HER), oxygen evolution reaction (OER), CO 2 reduction reaction (CO 2 RR) involved, the development of effective photo/electrocatalysts is critical to reduce the activation energy and accelerate the sluggish dynamics. Polyoxometalate (POM)‐based compounds with tunable compositions and...
Tue Jul 07, 2020 16:15
Now you see me, now you don‘t : CsPbBr3 nanocrystals embedded in porous SiO2 are hydrochromic. Upon exposure/removal of water, reversible transformation between luminescent CsPbBr3 and non‐luminescent CsPb2Br5 can be achieved. This hydrochromic material can be laser‐jet printed on substrates and used for anti‐counterfeiting. Abstract Hydrochromic materials that can reversibly change color upon water treatment have attracted much attention owing to their potential applications in diverse...
Tue Jul 07, 2020 15:25
A N‐hetero‐RhI‐metallacyclic silanone has been synthesized. This silanone is stable in solution at 60 °C and only slowly isomerizes at 120 °C, via an intramolecular C(sp3)−H bond insertion. This RhI‐substituted silanone can react either on the Si=O function or the Rh center, depending on the type of reagents.The reaction with H2, resulting in the hydrogenation of silanone moiety, proceeds via cooperative involvement of both sites. Abstract A novel N‐hetero‐RhI‐metallacyclic silanone 2...
Tue Jul 07, 2020 15:23
Moving towards the red : For the first time, the fluorescence of a cycloparaphenylene was dramatically red‐shifted without sacrificing quantum yield. This novel cycloparaphenylene has a strong absorption, high quantum yield and shows host–guest complexation with C60. Experimental and computational investigations explain its superior fluorescence properties compared to other red‐shifted nanohoops. Abstract Conjugated aromatic macrocycles are attractive due to their unique photophysical and...
Tue Jul 07, 2020 15:23
Heed the speed : A DNA origami‐based assay for the quantitative evaluation of tip effects in high‐speed atomic force microscopy (HS‐AFM) is presented. Using streptavidin–biotin as a model system, it is shown that the rapidly scanned AFM tip may disrupt even strongly binding biomolecular complexes with dissociation constants in the femtomolar range. Abstract High‐speed atomic force microscopy (HS‐AFM) is widely employed in the investigation of dynamic biomolecular processes at a single‐molecule...
Tue Jul 07, 2020 15:22
Multicolor swap shop : A facile doping approach for color‐tunable organic phosphorescence materials is enabled through hosts that not only restrict the molecular motion and avoid the triplet quenching from the oxygen, but also interact with the guests for the realization of phosphorescence. Color tunable, temperature dependent, and time‐resolved anti‐counterfeiting techniques are achieved by the printable and writable materials. Abstract Organic materials with long‐lived, color‐tunable...
Tue Jul 07, 2020 15:22
A spatial charge density (SCD) maximization strategy is developed to improve the energy density of capacitive charge storage, where ionic charges are densely and neatly packed in electrode materials. By balancing the valance and size of charge‐carrier ions and matching the ion sizes with the pore structure of electrode materials, a record high SCD of about 550 C cm−3 was achieved, nearly 5× conventional ones. Abstract Capacitive energy storage has advantages of high power density, long...
Tue Jul 07, 2020 15:21
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