Related Articles Tumor genomic alterations in severe-combined immunodeficiency bare-lymphocyte syndrome genes are associated with high mutational burden and disproportional neo-antigen rates. J Immunother Cancer. 2019 05 07;7(1):123 Authors: Wang Y, Johnson DB, Lu S, Diaz LA, Xu Y, Balko JM Abstract The progression of cancer requires mutational adaptation to permit unrestrained proliferation. A fraction of cancer mutations are oncogenic drivers,...
Wed Jul 08, 2020 13:40
Related Articles Haemophagocytic lymphohistiocytosis in patients treated with immune checkpoint inhibitors: analysis of WHO global database of individual case safety reports. J Immunother Cancer. 2019 05 02;7(1):117 Authors: Noseda R, Bertoli R, Müller L, Ceschi A Abstract BACKGROUND: Immune checkpoint inhibitor (ICI) use in clinical practice has unravelled a spectrum of immune-related adverse events (irAEs) due to immune system hyper-activation....
Wed Jul 08, 2020 13:40
Related Articles Polydopamine-coated magnetic mesoporous silica nanoparticles for multimodal cancer theranostics. J Mater Chem B. 2019 01 21;7(3):368-372 Authors: Shi M, Zhang J, Li J, Fan Y, Wang J, Sun W, Yang H, Peng C, Shen M, Shi X Abstract Polydopamine-coated magnetic mesoporous silica nanoparticles have been designed by loading ultrasmall iron oxide nanoparticles within hollow mesoporous silica nanopartricles and then coating polydopamine...
Wed Jul 08, 2020 13:40
Related Articles A Blue-Gray Macule on the Back: Challenge. Am J Dermatopathol. 2020 Jan;42(1):e4 Authors: Aderibigbe O, Groft-MacFarlane C, Chu EY PMID: 30308544 [PubMed - indexed for MEDLINE]
Wed Jul 08, 2020 13:40
Related Articles Analysis of wt1a reporter line expression levels during proepicardium formation in the zebrafish. Histol Histopathol. 2020 Jul 07;:18238 Authors: Andrés-Delgado L, Galardi-Castilla M, Mercader N, Santamaría L Abstract The epicardium is the outer mesothelial layer of the heart. It covers the myocardium and plays important roles in both heart development and regeneration. It is derived from the proepicardium (PE), groups of cells...
Wed Jul 08, 2020 19:41
Related Articles Cytotoxicity of sodium selenite in HaCaT cells induces cell death and alters the mRNA expression of PUMA, ATR, and mTOR genes. J Trace Elem Med Biol. 2020 Jul 02;62:126605 Authors: Bonfim NESMT, Baranoski A, Mantovani MS Abstract BACKGROUND: By identifying the molecular mechanisms underlying sodium selenite (Na2SeO3) cytotoxicity during exposure in non-tumor cells (HaCaT cells), we will improve the current understanding...
Wed Jul 08, 2020 14:36
Related Articles Structure guided design and synthesis of furyl thiazolidinedione derivatives as inhibitors of GLUT 1 and GLUT 4, and evaluation of their anti-leukemic potential. Eur J Med Chem. 2020 Jul 02;202:112603 Authors: Tilekar K, Upadhyay N, Hess JD, Macias LH, Mrowka P, Aguilera RJ, Meyer-Almes FJ, Iancu CV, Choe JY, Ramaa CS Abstract Cancer cells increase their glucose uptake and glycolytic activity to meet the high energy requirements...
Wed Jul 08, 2020 14:36
Related Articles Reduced graphene oxide mitigates cadmium-induced cytotoxicity and oxidative stress in HepG2 cells. Food Chem Toxicol. 2020 Jul 04;:111515 Authors: Ahamed M, Akhtar MJ, Khan MAM, Alhadlaq HA Abstract Numerous applications of reduced graphene oxide (RGO) and pervasive cadmium (Cd) have led concern about their co-exposure to the environment and human. We studied the combined effects of RGO and Cd in human liver (HepG2) cells....
Wed Jul 08, 2020 14:36
Related Articles A tetraprenylated benzophenone 7-epiclusianone induces cell cycle arrest at G1/S transition by modulating critical regulators of cell cycle in breast cancer cell lines. Toxicol In Vitro. 2020 Jul 04;:104927 Authors: da Silva Lamartine Hanemann S, Ferreira-Silva GÁ, de Oliveira Horvath R, Soncini R, Caixeta ES, Sales BR, de Oliveira Niero EL, Machado-Santelli GM, Dos Santos MH, de Oliveira JC, Miyazawa M, Ionta M Abstract ...
Wed Jul 08, 2020 14:36
Related Articles Overexpression of ABCB1 and ABCG2 contributes to reduced efficacy of the PI3K/mTOR inhibitor samotolisib (LY3023414) in cancer cell lines. Biochem Pharmacol. 2020 Jul 04;:114137 Authors: Wu CP, Hung CY, Lusvarghi S, Huang YH, Tseng PJ, Hung TH, Yu JS, Ambudkar SV Abstract LY3023414 (samotolisib) is a promising new dual inhibitor of phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR). Currently, multiple...
Wed Jul 08, 2020 14:36
Related Articles Antimalarial agent artesunate induces G0/G1 cell cycle arrest and apoptosis via increasing intracellular ROS levels in normal liver cells. Hum Exp Toxicol. 2020 Jul 07;:960327120937331 Authors: Yin S, Yang H, Zhao X, Wei S, Tao Y, Liu M, Bo R, Li J Abstract Artesunate (ARS) has been shown to be highly effective against chloroquine-resistant malaria. In vitro studies reported that ARS has anticancer effects; however, its...
Wed Jul 08, 2020 14:36
Related Articles Circ-ABCB10 acts as an oncogene in glioma cells via regulation of the miR-620/FABP5 axis. Eur Rev Med Pharmacol Sci. 2020 Jun;24(12):6848-6857 Authors: Sun WY, Lu YF, Cai XL, Li ZZ, Lv J, Xiang YA, Chen JJ, Chen WJ, Liu XM, Chen JB Abstract OBJECTIVE: This study aims to investigate the biological function of circular RNA ABCB10 (circ-ABCB10) in regulating the progression of glioma and to study the possible underlying mechanisms....
Wed Jul 08, 2020 14:36
Related Articles Linc00324 promotes the progression of papillary thyroid cancer via regulating Notch signaling pathway. Eur Rev Med Pharmacol Sci. 2020 Jun;24(12):6818-6824 Authors: Wan JF, Wan JY, Dong C, Li L Abstract OBJECTIVE: To explore the expression of linc00324 in papillary thyroid cancer (PTC) and its effect on the biological function of PTC cells. PATIENTS AND METHODS: A total of 60 pairs of PTC and para-carcinoma normal...
Wed Jul 08, 2020 14:36
Related Articles Simvastatin induces apoptosis of nasopharyngeal carcinoma cells through NF-κB signaling pathway. Eur Rev Med Pharmacol Sci. 2020 Jun;24(12):6726-6734 Authors: Sun FR, Wang SL, Wang M, Sun LM Abstract OBJECTIVE: The aim of this study was to investigate the mechanism of simvastatin-induced apoptosis in nasopharyngeal carcinoma (NPC) cells. MATERIALS AND METHODS: CNE1 and HK1 cell lines were treated with different...
Wed Jul 08, 2020 14:36
Related Articles Novel CXCR4 Inhibitor CPZ1344 Inhibits the Proliferation, Migration and Angiogenesis of Glioblastoma. Pathol Oncol Res. 2020 Jul 06;: Authors: Luo Z, Wang B, Chen Y, Liu H, Shi L Abstract Glioblastoma (GBM) are life-threatening tumors with a poor prognosis and low cure rates. GBMs are malignant brain tumors that develop from astrocytes. Most GBMs are not inherited and occur sporadically. GBM recurrence after standard treatment...
Wed Jul 08, 2020 14:36
Related Articles Inhibition of USP14 induces ER stress-mediated autophagy without apoptosis in lung cancer cell line A549. Cell Stress Chaperones. 2020 Jul 06;: Authors: Moghadami AA, Aboutalebi Vand Beilankouhi E, Kalantary-Charvadeh A, Hamzavi M, Mosayyebi B, Sedghi H, Ghorbani Haghjo A, Nazari Soltan Ahmad S Abstract Non-small cell lung cancer is the most common type of lung cancer, accounting for more than 80% of this tumor. Ubiquitin-specific...
Wed Jul 08, 2020 14:36
Related Articles Romidepsin (FK228) regulates the expression of the immune checkpoint ligand PD-L1 and suppresses cellular immune functions in colon cancer. Cancer Immunol Immunother. 2020 Jul 06;: Authors: Shi Y, Fu Y, Zhang X, Zhao G, Yao Y, Guo Y, Ma G, Bai S, Li H Abstract Romidepsin (FK228), a histone deacetylase inhibitor (HDACi), has anti-tumor effects against several types of solid tumors. Studies have suggested that HDACi could...
Wed Jul 08, 2020 14:36
Related Articles RNA-binding motif protein 43 (RBM43) suppresses hepatocellular carcinoma progression through modulation of cyclin B1 expression. Oncogene. 2020 Jul 06;: Authors: Feng H, Liu J, Qiu Y, Liu Y, Saiyin H, Liang X, Zheng F, Wang Y, Jiang D, Wang Y, Yu L, Su W, Shen S, Wu J Abstract RNA-binding proteins play key roles in the posttranscriptional regulation of mRNA during cancer progression. Here, we show that RNA-binding motif...
Wed Jul 08, 2020 14:36
Related Articles Robustaflavone induces G0/G1 cell cycle arrest and apoptosis in human umbilical vein endothelial cells and exhibits anti-angiogenic effects in vivo. Sci Rep. 2020 Jul 06;10(1):11070 Authors: Sim WK, Park JH, Kim KY, Chung IS Abstract We investigated the anti-angiogenic and pro-apoptotic effects of robustaflavone (RF), a naturally occurring biflavonoid, on human umbilical vein endothelial cells (HUVECs). RF inhibited HUVEC...
Wed Jul 08, 2020 14:36
Synthesis and biological evaluation of Schizandrin derivatives as tubulin polymerization inhibitors.
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Wed Jul 08, 2020 13:37
Related Articles Design, synthesis and biological evaluation of potent EGFR kinase inhibitors against 19D/T790M/C797S mutation. Bioorg Med Chem Lett. 2020 Aug 15;30(16):127327 Authors: Su Z, Yang T, Wang J, Lai M, Tong L, Wumaier G, Chen Z, Li S, Li H, Xie H, Zhao Z Abstract The efficacy of EGFR inhibitors is frequently affected by acquired resistance. EGFR19D/T790M/C797S mutation is one of the primary reasons for the emergence of resistance...
Wed Jul 08, 2020 13:37
Related Articles Design, synthesis and biological evaluation of new Myo-inositol derivatives as potential RAS inhibitors. Bioorg Med Chem Lett. 2020 Aug 15;30(16):127290 Authors: Hussain J, Chhabria D, Kirubakaran S Abstract Ras is a small family of GTPases that control numerous cellular functions like cell proliferation, growth, survival, gene expression, and is closely engaged in cancer pathogenesis. The ras-targeted methodology entails...
Wed Jul 08, 2020 13:37
Related Articles Metformin inhibits cervical cancer cell proliferation by modulating PI3K/Akt-induced major histocompatibility complex class I-related chain A gene expression. J Exp Clin Cancer Res. 2020 Jul 06;39(1):127 Authors: Xia C, Liu C, He Z, Cai Y, Chen J Abstract BACKGROUND: Recent studies have shown that the classic hypoglycemic drug metformin inhibits tumor growth; however, the underlying mechanism remains unclear. We previously...
Wed Jul 08, 2020 13:37
Related Articles Fusaric acid decreases p53 expression by altering promoter methylation and m6A RNA methylation in human hepatocellular carcinoma (HepG2) cells. Epigenetics. 2020 Jul 07;:1-13 Authors: Ghazi T, Nagiah S, Chuturgoon AA Abstract Fusaric acid (FA) is a food-borne mycotoxin that mediates toxicity with limited information on its epigenetic properties. p53 is a tumour suppressor protein that regulates cell cycle arrest and apoptotic...
Wed Jul 08, 2020 13:37
Related Articles Small RNA sequencing reveals miRNAs important for hypoxic adaptation in the Tibetan chicken. Br Poult Sci. 2020 Jul 07;: Authors: Zhang Z, Qiu M, Du H, Li Q, Yu C, Gan W, Peng H, Xia B, Xiong X, Song X, Yang L, Hu C, Chen J, Yang C, Jiang X Abstract This chicken, which is an indigenous breed living on the Tibetan Plateau, exhibits hypoxic adaptations to its high-altitude environment. However, the molecular mechanism behind...
Wed Jul 08, 2020 13:37
Related Articles The Phytochemical Indicaxanthin Synergistically Enhances Cisplatin-Induced Apoptosis in HeLa Cells via Oxidative Stress-Dependent p53/p21waf1 Axis. Biomolecules. 2020 Jul 02;10(7): Authors: Allegra M, D'Anneo A, Frazzitta A, Restivo I, Livrea MA, Attanzio A, Tesoriere L Abstract Combining phytochemicals with chemotherapics is an emerging strategy to treat cancer to overcome drug toxicity and resistance with natural compounds....
Wed Jul 08, 2020 13:37
Related Articles Therapeutic Editing of the TP53 Gene: Is CRISPR/Cas9 an Option? Genes (Basel). 2020 Jun 25;11(6): Authors: Mirgayazova R, Khadiullina R, Chasov V, Mingaleeva R, Miftakhova R, Rizvanov A, Bulatov E Abstract The TP53 gene encodes the transcription factor and oncosuppressor p53 protein that regulates a multitude of intracellular metabolic pathways involved in DNA damage repair, cell cycle arrest, apoptosis, and senescence....
Wed Jul 08, 2020 13:37
Related Articles The (+)-Brevipolide H Displays Anticancer Activity against Human Castration-Resistant Prostate Cancer: The Role of Oxidative Stress and Akt/mTOR/p70S6K-Dependent Pathways in G1 Checkpoint Arrest and Apoptosis. Molecules. 2020 Jun 25;25(12): Authors: Sheng YH, Leu WJ, Chen CN, Hsu JL, Liu YT, Hsu LC, Hou DR, Guh JH Abstract Because conventional chemotherapy is not sufficiently effective against prostate cancer, various examinations...
Wed Jul 08, 2020 13:37
Related Articles Loss of ZC4H2 and RNF220 Inhibits Neural Stem Cell Proliferation and Promotes Neuronal Differentiation. Cells. 2020 Jul 01;9(7): Authors: Zhang L, Ye M, Zhu L, Cha J, Li C, Yao YG, Mao B Abstract The ubiquitin E3 ligase RNF220 and its co-factor ZC4H2 are required for multiple neural developmental processes through different targets, including spinal cord patterning and the development of the cerebellum and the locus coeruleus....
Wed Jul 08, 2020 13:37
Related Articles Targeted Brain Tumor Therapy by Inhibiting the MDM2 Oncogene: In Vitro and In Vivo Antitumor Activity and Mechanism of Action. Cells. 2020 Jul 01;9(7): Authors: Punganuru SR, Artula V, Zhao W, Rajaei M, Deokar H, Zhang R, Buolamwini JK, Srivenugopal KS, Wang W Abstract There is a desperate need for novel and efficacious chemotherapeutic strategies for human brain cancers. There are abundant molecular alterations along the...
Wed Jul 08, 2020 13:37
Related Articles Cancer Stem Cell-Inducing Media Activates Senescence Reprogramming in Fibroblasts. Cancers (Basel). 2020 Jun 30;12(7): Authors: Perrigue PM, Rakoczy M, Pawlicka KP, Belter A, Giel-Pietraszuk M, Naskręt-Barciszewska M, Barciszewski J, Figlerowicz M Abstract Cellular senescence is a tumor-suppressive mechanism blocking cell proliferation in response to stress. However, recent evidence suggests that senescent tumor cells can...
Wed Jul 08, 2020 13:37
Related Articles Chemopreventive Agent 3,3'-Diindolylmethane Inhibits MDM2 in Colorectal Cancer Cells. Int J Mol Sci. 2020 Jun 30;21(13): Authors: Gao X, Liu J, Cho KB, Kedika S, Guo B Abstract 3,3'-Diindolylmethane (DIM) is a naturally derived chemopreventive compound. It comes from glucobrassicin, an indole glucosinolate enriched in cruciferous vegetables, and is formed in the acidic environment of the stomach after ingestion. Mouse double...
Wed Jul 08, 2020 13:37
Related Articles Picropodophyllotoxin, an Epimer of Podophyllotoxin, Causes Apoptosis of Human Esophageal Squamous Cell Carcinoma Cells Through ROS-Mediated JNK/P38 MAPK Pathways. Int J Mol Sci. 2020 Jun 30;21(13): Authors: Kwak AW, Yoon G, Lee MH, Cho SS, Shim JH, Chae JI Abstract Esophageal squamous cell carcinoma (ESCC), a major histologic type of esophageal cancer, is one of the frequent causes of cancer-related death worldwide. Picropodophyllotoxin...
Wed Jul 08, 2020 13:37
Related Articles Regulatory Mechanisms of Inhibitory Immune Checkpoint Receptors Expression. Trends Cell Biol. 2019 10;29(10):777-790 Authors: Curdy N, Lanvin O, Laurent C, Fournié JJ, Franchini DM Abstract T cells responding to persistent tumor or viral antigens progressively lose their functional properties, a feature known as exhaustion. This state is also characterized by cell-surface expression of multiple inhibitory immune checkpoint...
Wed Jul 08, 2020 13:37
Related Articles BmGeminin2 interacts with BmRRS1 and regulates Bombyx mori cell proliferation. Cell Cycle. 2019 07;18(13):1498-1512 Authors: Zhou XL, Wei Y, Chen XY, Chen P, Tang XF, Zhang Q, Dong ZQ, Pan MH, Lu C Abstract Geminin is a master regulator of cell-cycle progression that ensures the timely onset of DNA replication and prevents re-replication in vertebrates and invertebrates. Previously, we identified two Geminin genes, BmGeminin1...
Wed Jul 08, 2020 13:37
Related Articles A Slug-dependent mechanism is responsible for tumor suppression of p53-stabilizing compound CP-31398 in p53-mutated endometrial carcinoma. J Cell Physiol. 2020 Jul 06;: Authors: Liu L, Yu ZY, Yu TT, Cui SH, Yang L, Chang H, Qu YH, Lv XF, Zhang XA, Ren CC Abstract Mutation in the tumor suppressor gene p53 is the most frequent molecular defect in endometrial carcinoma (EC). Recently, CP-31398, a p53-stabilizing compound, has been...
Wed Jul 08, 2020 17:36
Related Articles Carnitine palmitoyltransferase 1C reverses cellular senescence of MRC-5 fibroblasts via regulating lipid accumulation and mitochondrial function. J Cell Physiol. 2020 Jul 06;: Authors: Chen P, Zhang Q, Zhang H, Gao Y, Zhou Y, Chen Y, Guan L, Jiao T, Zhao Y, Huang M, Bi H Abstract Cellular senescence, a state of growth arrest, is involved in various age-related diseases. We previously found that carnitine palmitoyltransferase...
Wed Jul 08, 2020 17:36
Publication date: August 2020Source: Journal of Human Evolution, Volume 145Author(s): Angel Zeininger, Daniel Schmitt, Roshna E. Wunderlich
Wed Jul 08, 2020 13:33
Related Articles [The possible mechanisms of simvastatin on apoptosis of lung adenocarcinoma cells]. Zhonghua Yi Xue Za Zhi. 2020 Jul 07;100(25):1988-1994 Authors: Wu QG, Zhu JJ, Ma DB, Wang Y, Li YJ, Cai TP, Wang J Abstract Objective: To explore the possible mechanisms of simvastatin-induced apoptosis in lung adenocarcinoma cells. Methods: The experiment was divided into control group (vehicle treated A549 cells), different concentrations (10,...
Wed Jul 08, 2020 13:27
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