Abstract Our understanding of IgE‐mediated drug allergy relies on the hapten concept, which is well established in inducing adaptive reactions of the immune system to small molecules like drugs. The role of hapten‐carrier adductsin re‐challenge reactions leading to mast cell degranulation and anaphylaxis is unclear. Based on clinical observations, the speed of adduct formation, skin and in‐vitro tests to inert drug molecules, a different explanation of IgE‐mediated reactions to drugs is proposed:...
Tue Aug 11, 2020 17:22
Abstract Background Allergy to bites of blood sucking insects, including biting midges can affect both human and veterinary patients. Horses are often suffering from an IgE‐mediated allergic dermatitis caused by bites of midges (Culicoides spp) . With the aim to improve allergen immunotherapy (AIT) numerous Culicoides allergens have been produced as recombinant (r‐) proteins. This study aims to test a comprehensive panel of differently expressed Culicoides r‐allergens on a cohort of IBH‐affected...
Tue Aug 11, 2020 17:20
Abstract Drug hypersensitivity reactions (DHRs) represent a global threat to healthcare systems due to their incidence, with a significant increase over last years
Tue Aug 11, 2020 17:15
Abstract Our climate is changing at an unprecedented rate. This not only has impacts on the planet and the ecosystem, with extinction rates rising rapidly, but also on human health (Figure 1). The effects of climate change are and will continue to disrupt the basic requirements for health such as clean water, clean air, adequate food and will furthermore exacerbate underlying social, economic, and ecological
Tue Aug 11, 2020 14:39
Publication date: Available online 11 August 2020Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Xingnan Li, Stephanie A. Christenson, Brian Modena, Huashi Li, William W. Busse, Mario Castro, Loren C. Denlinger, Serpil C. Erzurum, John V. Fahy, Benjamin Gaston, Annette T. Hastie, Elliot Israel, Nizar N. Jarjour, Bruce D. Levy, Wendy C. Moore, Prescott G. Woodruff, Naftali Kaminski, Sally E. Wenzel, Eugene R. Bleecker, Deborah A. Meyers
Wed Aug 12, 2020 16:09
Publication date: Available online 11 August 2020Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Maria Suprun, Scott H. Sicherer, Robert A. Wood, Stacie M. Jones, Donald Y.M. Leung, Alice K. Henning, Peter Dawson, A. Wesley Burks, Robert Lindblad, Robert Getts, Mayte Suárez-Fariñas, Hugh A. Sampson
Wed Aug 12, 2020 16:09
Publication date: Available online 11 August 2020Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Masayuki Nakajima, Masashi Matsuyama, Naoki Arai, Hideyasu Yamada, Kentaro Hyodo, Mizu Nonaka, Haruna Kitazawa, Kazufumi Yoshida, Rie Shigemasa, Yuko Morishima, Takumi Kiwamoto, Hironori Masuko, Yukio Ishii, Masafumi Muratani, Takefumi Saito, Nobuyuki Hizawa
Wed Aug 12, 2020 16:09
Penicillin allergy is commonly reported. In pregnant women, reported penicillin allergy is associated with negative health outcomes and suboptimal group B streptococcal prophylaxis. For penicillin allergic individuals, skin testing followed by observed oral challenge is recommended. Prior data demonstrate a low risk of adverse reaction with skin testing in pregnant women, but subsequent oral challenge was not routinely pursued.
Wed Aug 12, 2020 03:00
Background Chronic rhinosinusitis (CRS) is associated with sleep dysfunction, but the underlying pathophysiology is poorly understood. The purpose of this study was to determine if mucosal eosinophilia or neutrophilia were associated with sleep dysfunction severity or altered the improvement in sleep dysfunction following functional endoscopic sinus surgery (FESS). Methods A total of 104 patients with medically refractory CRS with nasal polyposis (CRSwNP) and CRS without nasal polyposis (CRSsNP),...
Tue Aug 11, 2020 20:00
After the approval of immune checkpoint inhibitors for the treatment of many solid tumors, a new class of adverse events was recognized through the augmented activation of T cells, known as immune-related toxicities (immune-related adverse events). Encephalitis as an immune-mediated phenomenon is extremely rare, but potentially fatal, and questions remain with regard to its optimal management. Herein, we describe a patient with metastatic melanoma who developed autoimmune encephalitis following treatment...
Wed Aug 12, 2020 20:43
Salmonella has been shown to preferentially colonize solid tumors. It is known that toxicity limits the systemic administration of immunomodulatory cytokines that have a significant anticancer effect. Therefore, we tested a unique cancer treatment strategy comprised of oral delivery of Saltikva, an attenuated strain of Salmonella typhimurium that contain the human gene for interleukin-2. In preclinical experimentation, a significant antitumor effect without toxicity was observed. A dose escalation,...
Wed Aug 12, 2020 20:43
Increasing numbers of head and neck cancer patients are placed on immune checkpoint inhibitors for indications such as recurrent and metastatic disease. There is a theoretical increased risk of contracting and reactivation of tuberculosis (TB) with programmed cell death-1 blockade due to potentiation of type 1 T helper response and increased production of interferon-gamma. This is a potentially life-threatening complication of therapy and requires expedient diagnosis and treatment. We present a case...
Wed Aug 12, 2020 20:43
No abstract available
Wed Aug 12, 2020 20:43
Publication date: Available online 12 August 2020Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): Yi-Tsen Lin, Ming-Hung Lin, Kuen-Yuh Wu, Yungling Leo Lee
Wed Aug 12, 2020 16:07
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