Antibiotics, Vol. 9, Pages 508: A Quantitative Survey of Bacterial Persistence in the Presence of Antibiotics: Towards Antipersister Antimicrobial Discovery Antibiotics doi: 10.3390/antibiotics9080508 Authors: Jesus Enrique Salcedo-Sora Douglas B. Kell Background: Bacterial persistence to antibiotics relates to the phenotypic ability to survive lethal concentrations of otherwise bactericidal antibiotics. The quantitative nature of the time–kill assay, which is the sector’s...
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Antibiotics, Vol. 9, Pages 507: Implementation of the WHO Approved “Tailoring Antimicrobial Resistance Programs (TAP)” Reduces Patients’ Request for Antibiotics Antibiotics doi: 10.3390/antibiotics9080507 Authors: Nasser M. Kaplan Yousef S. Khader Mahmoud A. Alfaqih Rami Saadeh Lora Al Sawalha The misuse of antibiotics is a worldwide public health concern. Behavioral Intervention programs that aim to reduce patients’ own request for antibiotics during their visit...
Wed Aug 12, 2020 03:00
Antibiotics, Vol. 9, Pages 506: Copper Kills Escherichia coli Persister Cells Antibiotics doi: 10.3390/antibiotics9080506 Authors: Paula Maria Moreira Martins Ting Gong Alessandra A. de Souza Thomas K. Wood Due to their reduced metabolism, persister cells can survive most antimicrobial treatments, which usually rely on corrupting active biochemical pathways. Therefore, molecules that kill bacterial persisters should function in a metabolism-independent manner. Some anti-persister...
Wed Aug 12, 2020 03:00
Antibiotics, Vol. 9, Pages 505: E-Health Tools to Improve Antibiotic Use and Resistances: A Systematic Review Antibiotics doi: 10.3390/antibiotics9080505 Authors: Érico Carvalho Marta Estrela Maruxa Zapata-Cachafeiro Adolfo Figueiras Fátima Roque Maria Teresa Herdeiro (1) Background: e-Health tools, especially in the form of clinical decision support systems (CDSSs), have been emerging more quickly than ever before. The main objective of this systematic review is to assess...
Wed Aug 12, 2020 03:00
Antioxidants, Vol. 9, Pages 742: Hesperidin and SARS-CoV-2: New Light on the Healthy Function of Citrus Fruits Antioxidants doi: 10.3390/antiox9080742 Authors: Paolo Bellavite Alberto Donzelli Among the many approaches to Coronavirus disease 2019 (COVID-19) prevention, the possible role of nutrition has so far been rather underestimated. Foods are very rich in substances, with a potential beneficial effect on health, and some of these could have an antiviral action or be important...
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Antioxidants, Vol. 9, Pages 739: Cigarette Smoke Extract Stimulates MMP-2 Production in Nasal Fibroblasts via ROS/PI3K, Akt, and NF-κB Signaling Pathways Antioxidants doi: 10.3390/antiox9080739 Authors: Joo-Hoo Park Jae-Min Shin Hyun-Woo Yang Tae Hoon Kim Seung Hoon Lee Heung-Man Lee Jae-Gu Cho Il-Ho Park Cigarette smoke exposure has been shown to be associated with chronic rhinosinusitis and tissue remodeling. The present study aimed to investigate the effects of...
Wed Aug 12, 2020 03:00
Antioxidants, Vol. 9, Pages 741: Exploring Seminal Plasma GSTM3 as a Quality and In Vivo Fertility Biomarker in Pigs—Relationship with Sperm Morphology Antioxidants doi: 10.3390/antiox9080741 Authors: Marc Llavanera Ariadna Delgado-Bermúdez Yentel Mateo-Otero Lorena Padilla Xavier Romeu Jordi Roca Isabel Barranco Marc Yeste Glutathione S-transferases Mu 3 (GSTM3) is an essential antioxidant enzyme whose presence in sperm has recently been related to sperm cryotolerance,...
Wed Aug 12, 2020 03:00
Antioxidants, Vol. 9, Pages 737: Super-Resolution Microscopy Reveals an Altered Fibrin Network in Cirrhosis: The Key Role of Oxidative Stress in Fibrinogen Structural Modifications Antioxidants doi: 10.3390/antiox9080737 Authors: Matteo Becatti Amanda Mannucci Flavia Rita Argento Stefano Gitto Francesco Vizzutti Fabio Marra Niccolò Taddei Claudia Fiorillo Giacomo Laffi Cirrhotic patients show a reduced synthesis of both pro- and anti-coagulant factors. Recent...
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Antioxidants, Vol. 9, Pages 738: Is Sleep Associated with the S-Klotho Anti-Aging Protein in Sedentary Middle-Aged Adults? The FIT-AGEING Study Antioxidants doi: 10.3390/antiox9080738 Authors: Sol Mochón-Benguigui Almudena Carneiro-Barrera Manuel J. Castillo Francisco J. Amaro-Gahete Sleep and Klotho have both been closely related to the ageing process, both playing a substantial role in the endocrine and immune systems and, thereby, in oxidative stress and chronic inflammation....
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Antioxidants, Vol. 9, Pages 740: When It Comes to an End: Oxidative Stress Crosstalk with Protein Aggregation and Neuroinflammation Induce Neurodegeneration Antioxidants doi: 10.3390/antiox9080740 Authors: Michalska León Neurodegenerative diseases are characterized by a progressive loss of neurons in the brain or spinal cord that leads to a loss of function of the affected areas. The lack of effective treatments and the ever-increasing life expectancy is raising the number of individuals...
Wed Aug 12, 2020 03:00
Arts, Vol. 9, Pages 89: Traditions in the Discussions about the obrabotvane of Folklore in the Avtorski Pesni v Naroden Duh from Bulgaria Arts doi: 10.3390/arts9030089 Authors: Lozanka Peycheva The avtorski pesni v naroden duh (authored songs in folk spirit) are a modern and multifaceted phenomenon, which has accumulated a rich history in Bulgarian musical culture. This research presents the essential characteristics of these songs and a two-part typology (1. authorized/avtorizirani...
Wed Aug 12, 2020 03:00
Atmosphere, Vol. 11, Pages 853: Arable Weed Patterns According to Temperature and Latitude Gradient in Central and Southern Spain Atmosphere doi: 10.3390/atmos11080853 Authors: María Luisa Gandía Carlos Casanova Francisco Javier Sánchez José Luís Tenorio María Inés Santín-Montanyá (1) Background: In agro-ecosystems, the success of the crops has a strong connection to biodiversity in the landscape. In the face of climate change, it is important to understand the response to...
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Atmosphere, Vol. 11, Pages 852: An Air Pollutant Emission Reduction Path of China’s Power Industry Atmosphere doi: 10.3390/atmos11080852 Authors: Yue Yu Zhi-xin Jin Ji-zu Li Yu-cheng Wu Li Jia In China, as the major source of energy consumption and air pollutant emissions, the power industry is not only the principal force that bears the responsibility of national emission reduction targets but also a breakthrough that reflects the effectiveness of emission reduction. In...
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Atmosphere, Vol. 11, Pages 850: Weather Effects of Aerosols in the Global Forecast Model Atmosphere doi: 10.3390/atmos11080850 Authors: Jeong The weather effects of aerosol types were investigated using well-posed aerosol climatology through the aerosol sensitivity test of thermodynamic and hydrometeor fields, and the weather forecast performances in July of 2017. The largest aerosol direct radiative forcing (ADRF) in July was due to dust aerosols at the surface and atmosphere, and...
Wed Aug 12, 2020 03:00
Atmosphere, Vol. 11, Pages 851: Geophysical and Social Influences on Evacuation Decision-Making: The Case of Hurricane Irma Atmosphere doi: 10.3390/atmos11080851 Authors: Robin L. Ersing Christianne Pearce Jennifer Collins Michelle E. Saunders Amy Polen Understanding the factors that influence evacuation decision-making among local residents is of critical importance to those involved in monitoring and managing weather-related hazards. This study examined both geophysical...
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Biology, Vol. 9, Pages 220: Mathematical Parameters of the COVID-19 Epidemic in Brazil and Evaluation of the Impact of Different Public Health Measures Biology doi: 10.3390/biology9080220 Authors: Renato M. Cotta Carolina P. Naveira-Cotta Pierre Magal A SIRU-type epidemic model is employed for the prediction of the COVID-19 epidemy evolution in Brazil, and analyze the influence of public health measures on simulating the control of this infectious disease. The proposed model allows...
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Biomolecules, Vol. 10, Pages 1176: The Role of Fe, Zn, and Cu in Pregnancy Biomolecules doi: 10.3390/biom10081176 Authors: Grzeszczak Kwiatkowski Kosik-Bogacka Iron (Fe), copper (Cu), and zinc (Zn) are microelements essential for the proper functioning of living organisms. These elements participatein many processes, including cellular metabolism and antioxidant and anti-inflammatory defenses, and also influence enzyme activity, regulate gene expression, and take part in protein...
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Biomolecules, Vol. 10, Pages 1177: Contactin-1 Is Reduced in Cerebrospinal Fluid of Parkinson’s Disease Patients and Is Present within Lewy Bodies Biomolecules doi: 10.3390/biom10081177 Authors: Madhurima Chatterjee Inger van Steenoven Evelien Huisman Linda Oosterveld Henk Berendse Wiesje M. van der Flier Marta Del Campo Afina W. Lemstra Wilma D. J. van de Berg Charlotte E. Teunissen Synaptic degeneration is an early phenomenon in Parkinson’s disease...
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Biomolecules, Vol. 10, Pages 1174: Peroxisomal Cofactor Transport Biomolecules doi: 10.3390/biom10081174 Authors: Anastasija Plett Lennart Charton Nicole Linka Peroxisomes are eukaryotic organelles that are essential for growth and development. They are highly metabolically active and house many biochemical reactions, including lipid metabolism and synthesis of signaling molecules. Most of these metabolic pathways are shared with other compartments, such as Endoplasmic reticulum...
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Biomolecules, Vol. 10, Pages 1175: DNA Phosphorothioate Modifications Are Widely Distributed in the Human Microbiome Biomolecules doi: 10.3390/biom10081175 Authors: Yihua Sun Lingxin Kong Guojun Wu Bo Cao Xiaoyan Pang Zixin Deng Peter C. Dedon Chenhong Zhang Delin You The DNA phosphorothioate (PT) modification existing in many prokaryotes, including bacterial pathogens and commensals, confers multiple characteristics, including restricting gene transfer, influencing...
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Biosensors, Vol. 10, Pages 98: Docking Simulation and Sandwich Assay for Aptamer-Based Botulinum Neurotoxin Type C Detection Biosensors doi: 10.3390/bios10080098 Authors: In-Hwan Oh Dae-Young Park Ji-Man Cha Woo-Ri Shin Ji-Young Ahn Yang-Hoon Kim Ji Hun Kim Sun Chang Kim Byung-Kwan Cho Aptamers are biomaterials that bind to a target molecule through a unique structure, and have high applicability in the diagnostic and medical fields. To effectively utilize aptamers,...
Wed Aug 12, 2020 03:00
Brain Sciences, Vol. 10, Pages 548: Effect of Cladribine on Neuronal Apoptosis: New Insight of In Vitro Study in Multiple Sclerosis Therapy Brain Sciences doi: 10.3390/brainsci10080548 Authors: Maddalena Ruggieri Concetta Domenica Gargano Anna Ferretta Alessia Manni Antonio Capacchione Antonio Frigeri Pietro Iaffaldano Maria Trojano Damiano Paolicelli Background: Cladribine (2-CdA) can cross the blood–brain barrier, resulting in inhibition of DNA synthesis...
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Brain Sciences, Vol. 10, Pages 549: Different Effects of Transcranial Direct Current Stimulation on Leg Muscle Glucose Uptake Asymmetry in Two Women with Multiple Sclerosis Brain Sciences doi: 10.3390/brainsci10080549 Authors: Alexandra C. Fietsam Craig D. Workman Laura L. Boles Ponto John Kamholz Thorsten Rudroff Asymmetrical lower limb strength is a significant contributor to impaired walking abilities in people with multiple sclerosis (PwMS). Transcranial direct current...
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Brain Sciences, Vol. 10, Pages 547: Cognitive Function Improvement in Mouse Model of Alzheimer’s Disease Following Transcranial Direct Current Stimulation Brain Sciences doi: 10.3390/brainsci10080547 Authors: Wang-In Kim Jae-Young Han Min-Keun Song Hyeng-Kyu Park Jihoon Jo Anodal transcranial direct current stimulation (tDCS) is a painless noninvasive method that reportedly improves cognitive function in Alzheimer’s disease (AD) by stimulating the brain. However,...
Wed Aug 12, 2020 03:00
Brain Sciences, Vol. 10, Pages 546: Cerebral Hemodynamic Changes to Transcranial Doppler in Asymptomatic Patients with Fabry’s Disease Brain Sciences doi: 10.3390/brainsci10080546 Authors: Carla Vagli Francesco Fisicaro Luisa Vinciguerra Valentina Puglisi Margherita Stefania Rodolico Antonello Giordano Raffaele Ferri Giuseppe Lanza Rita Bella Background: Patients with Fabry’s disease (FD) may be asymptomatic or show a spectrum of clinical manifestations,...
Wed Aug 12, 2020 03:00
Brain Sciences, Vol. 10, Pages 544: Associations between Attention and Implicit Associative Learning in Healthy Adults: The Role of Cortisol and Salivary Alpha-Amylase Responses to an Acute Stressor Brain Sciences doi: 10.3390/brainsci10080544 Authors: Linda Becker Nicolas Rohleder In this study, we investigated the associations between implicit associative learning with the cortisol and salivary alpha-amylase (sAA) stress response to an acute stressor as well as their associations...
Wed Aug 12, 2020 03:00
Brain Sciences, Vol. 10, Pages 545: Differential Expression of Multiple Disease-Related Protein Groups Induced by Valproic Acid in Human SH-SY5Y Neuroblastoma Cells Brain Sciences doi: 10.3390/brainsci10080545 Authors: Tsung-Ming Hu Hsiang-Sheng Chung Lieh-Yung Ping Shih-Hsin Hsu Hsin-Yao Tsai Shaw-Ji Chen Min-Chih Cheng Valproic acid (VPA) is a multifunctional medication used for the treatment of epilepsy, mania associated with bipolar disorder, and migraine. The pharmacological...
Wed Aug 12, 2020 03:00
Cancers, Vol. 12, Pages 2261: MiR-302b as a Combinatorial Therapeutic Approach to Improve Cisplatin Chemotherapy Efficacy in Human Triple-Negative Breast Cancer Cancers doi: 10.3390/cancers12082261 Authors: Alessandra Cataldo Sandra Romero-Cordoba Ilaria Plantamura Giulia Cosentino Alfredo Hidalgo-Miranda Elda Tagliabue Marilena V. Iorio Introduction: Chemotherapy is still the standard of care for triple-negative breast cancers (TNBCs). Here, we investigated miR-302b...
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Cancers, Vol. 12, Pages 2260: Anti-cancer Immunotherapies Targeting Telomerase Cancers doi: 10.3390/cancers12082260 Authors: Negrini De Palma Filaci Telomerase is a reverse transcriptase that maintains telomeres length, compensating for the attrition of chromosomal ends that occurs during each replication cycle. Telomerase is expressed in germ cells and stem cells, whereas it is virtually undetectable in adult somatic cells. On the other hand, telomerase is broadly expressed...
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Cancers, Vol. 12, Pages 2263: Uptake Transporters of the SLC21, SLC22A, and SLC15A Families in Anticancer Therapy—Modulators of Cellular Entry or Pharmacokinetics? Cancers doi: 10.3390/cancers12082263 Authors: Brecht Schäfer Meyer zu Schwabedissen Solute carrier transporters comprise a large family of uptake transporters involved in the transmembrane transport of a wide array of endogenous substrates such as hormones, nutrients, and metabolites as well as of clinically important...
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Cancers, Vol. 12, Pages 2259: Correlation of RECIST, Computed Tomography Morphological Response, and Pathological Regression in Hepatic Metastasis Secondary to Colorectal Cancer: The AVAMET Study Cancers doi: 10.3390/cancers12082259 Authors: Ruth Vera María Luisa Gómez Juan Ramón Ayuso Joan Figueras Pilar García-Alfonso Virginia Martínez Adelaida Lacasta Ana Ruiz-Casado María José Safont Jorge Aparicio Juan Manuel Campos Juan Carlos Cámara Marta Martín-Richard...
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Cancers, Vol. 12, Pages 2257: A Global Gene Body Methylation Measure Correlates Independently with Overall Survival in Solid Cancer Types Cancers doi: 10.3390/cancers12082257 Authors: Pils Steindl Bachmayr-Heyda Dekan Aust Epigenetics, CpG methylation of CpG islands (CGI) and gene bodies (GBs), plays an important role in gene regulation and cancer biology, the former established as a transcription regulator. Genome wide CpG methylation, summarized over GBs and CGIs,...
Wed Aug 12, 2020 03:00
Cancers, Vol. 12, Pages 2253: MDM2 Antagonists Induce a Paradoxical Activation of Erk1/2 through a P53-Dependent Mechanism in Dedifferentiated Liposarcomas: Implications for Combinatorial Strategies Cancers doi: 10.3390/cancers12082253 Authors: Shomereeta Roy Audrey Laroche-Clary Stephanie Verbeke Marie-Alix Derieppe Antoine Italiano The MDM2 gene is amplified in dedifferentiated liposarcoma (DDLPS). Treatment with MDM2 antagonists is a promising strategy to treat DDLPS;...
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Cancers, Vol. 12, Pages 2256: Long-Term Treatment of Cancer-Associated Thrombosis (CAT) Beyond 6 Months in the Medical Practice: USCAT, a 432-Patient Retrospective Non-Interventional Study Cancers doi: 10.3390/cancers12082256 Authors: Isabelle Mahé Ludovic Plaisance Céline Chapelle Silvy Laporte Benjamin Planquette Laurent Bertoletti Francis Couturaud Nicolas Falvo Lionel Falchero Isild Mahé Hélène Helfer Jean Chidiac Guy Meyer Background: extended...
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Cancers, Vol. 12, Pages 2254: MiR-155-5p and MiR-203a-3p Are Prognostic Factors in Soft Tissue Sarcoma Cancers doi: 10.3390/cancers12082254 Authors: Thomas Greither Franziska Koser Hans-Jürgen Holzhausen Antje Güttler Peter Würl Matthias Kappler Sven Wach Helge Taubert Soft tissue sarcoma (STS) is a heterogeneous group of rare malignancies with a five-year survival rate of approximately 50%. Reliable molecular markers for risk stratification and subsequent therapy...
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Cancers, Vol. 12, Pages 2255: Prediction of Response and Survival Following Treatment with Azacitidine for Relapse of Acute Myeloid Leukemia and Myelodysplastic Syndromes after Allogeneic Hematopoietic Stem Cell Transplantation Cancers doi: 10.3390/cancers12082255 Authors: Christina Rautenberg Anika Bergmann Ulrich Germing Caroline Fischermanns Sabrina Pechtel Jennifer Kaivers Paul Jäger Esther Schuler Rainer Haas Guido Kobbe Thomas Schroeder To provide...
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Cancers, Vol. 12, Pages 2258: Neoadjuvant Radiotherapy-Related Wound Morbidity in Soft Tissue Sarcoma: Perspectives for Radioprotective Agents Cancers doi: 10.3390/cancers12082258 Authors: Cameron M. Callaghan M. M. Hasibuzzaman Samuel N. Rodman Jessica E. Goetz Kranti A. Mapuskar Michael S. Petronek Emily J. Steinbach Benjamin J. Miller Casey F. Pulliam Mitchell C. Coleman Varun V. Monga Mohammed M. Milhem Douglas R. Spitz Bryan G. Allen Historically,...
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Cancers, Vol. 12, Pages 2251: Neoadjuvant Systemic Treatment of Primary Angiosarcoma Cancers doi: 10.3390/cancers12082251 Authors: Kimberley M. Heinhuis Nikki S. IJzerman Winette T. A. van der Graaf Jan Martijn Kerst Yvonne Schrage Jos H. Beijnen Neeltje Steeghs Winan J. van Houdt Angiosarcoma is an extremely rare and aggressive malignancy. Standard of care of localized tumors includes surgery ± radiation. Despite this multimodal treatment, >50%...
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Cancers, Vol. 12, Pages 2252: Targeting Glucose Metabolism to Overcome Resistance to Anticancer Chemotherapy in Breast Cancer Cancers doi: 10.3390/cancers12082252 Authors: Elizabeth Varghese Samson Mathews Samuel Alena Líšková Marek Samec Peter Kubatka Dietrich Büsselberg Breast cancer (BC) is the most prevalent cancer in women. BC is heterogeneous, with distinct phenotypical and morphological characteristics. These are based on their gene expression profiles, which divide...
Wed Aug 12, 2020 03:00
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