Background Pay‐for‐performance reimbursement ties hospital payments to standardized quality‐of‐care metrics. To the authors' knowledge, the impact of pay‐for‐performance reimbursement models on hospitals caring primarily for uninsured or underinsured patients remains poorly defined. The objective of the current study was to evaluate how standardized quality‐of‐care metrics vary by a hospital's propensity to care for uninsured or underinsured patients and demonstrate the potential impact that pay‐for‐performance...
Tue Aug 11, 2020 17:55
Background In the wake of the coronavirus disease 2019 (COVID‐19) pandemic, access to surgical care for patients with head and neck cancer (HNC) is limited and unpredictable. Determining which patients should be prioritized is inherently subjective and difficult to assess. The authors have proposed an algorithm to fairly and consistently triage patients and mitigate the risk of adverse outcomes. Methods Two separate expert panels, a consensus panel (11 participants) and a validation panel...
Tue Aug 11, 2020 17:47
Background Evidence of the effects of cancer prevention knowledge on the risk of developing cancer remains scarce. The objective of this study was to prospectively examine the association of cancer prevention awareness levels with cancer risk in a population‐based cancer screening cohort in China. Methods This prospective cohort study included 164,341 participants aged 40 to 69 years with no history of cancer and with available information on cancer prevention core knowledge in the Esophageal,...
Tue Aug 11, 2020 17:29
Background Approximately 40% of patients with cancer also have another chronic medical condition. Patient‐centered medical homes (PCMHs) have improved outcomes among patients with multiple chronic comorbidities. The authors first evaluated the impact of a cancer diagnosis on chronic medication adherence among patients with Medicaid coverage and, second, whether PCMHs influenced outcomes among patients with cancer. Methods Using linked 2004 to 2010 North Carolina cancer registry and claims...
Tue Aug 11, 2020 17:28
Background Invasive lobular breast cancer (BC) is the second most common BC subtype. Prognostic parameters (tumor classification, lymph node status, histologic grade, Oncotype DX recurrence score [RS], progesterone receptor status, and Ki67 index) were retrospectively studied in a large, prospective clinical trial encompassing 2585 patients who had hormone receptor‐positive early BC (the West German Study Group PlanB trial). Methods BCs were centrally reviewed and classified as lobular (n = 353;...
Tue Aug 11, 2020 17:23
Background To the authors' knowledge, the empiric identification of agents and interventions to mitigate chemotherapy‐induced peripheral neuropathy (CIPN) has resulted in only 1 agent that modestly mitigates it and no agents or interventions that prevent its development. This speaks to the need for a mechanistic understanding of CIPN to develop effective interventions. Methods To understand the extent to which mechanistic understanding of CIPN is being translated into the development of interventions,...
Tue Aug 11, 2020 17:22
Background Cervical cancer is a preventable cancer; therefore, countries should provide strategic, evidence‐based health services to reduce its incidence and impact on their populations. Two packages of health services that group together all the services related to cervical cancer, the Essential Cancer Package (9 interventions) and the Primary Care Package (5 interventions), are defined in this article with the aim of assessing the global status of the availability of health services and their...
Tue Aug 11, 2020 17:19
Tue Aug 11, 2020 17:18
Background Mitotic rate is a strong, independent prognostic factor in patients with melanoma. However, incorporating it into the melanoma staging system has proved challenging. Methods The prognostic impact of mitotic rate was assessed in a melanoma cohort comprising 5050 patients from 2 geographically distinct populations. Computer‐generated cut points for mitotic rate were constructed to determine its impact on melanoma‐associated survival using Kaplan‐Meier and multivariate regression analyses....
Tue Aug 11, 2020 17:15
Abstract Molecular‐targeted drugs specifically interfere with molecules that are frequently overexpressed or mutated in cancer cells. As such, these drugs are generally considered to precisely attack cancer cells, thereby inducing fewer adverse drug reactions (ADRs). However, molecular‐targeted drugs can still cause characteristic ADRs that, although rarely severe, can be life‐threatening. Therefore, it is becoming increasingly important to be able to predict which patients are at risk of developing...
Tue Aug 11, 2020 17:28
Summary The pioneering work from Chen’s lab identified Siglec‐15 as novel tumor immune suppressor, while the regulatory mechanisms underlying the broad up‐regulation of Siglec‐15 in human cancers were obscure currently. Here we found long non‐coding RNA (lncRNA) LINC00973 was higher in Siglec‐15‐positive clear‐cell renal cell carcinoma (ccRCC), and LINC00973 positively regulated Siglec‐15 expression at transcriptional level. This effect was evidently dependent on miR‐7109‐3p (designated as miR‐7109...
Tue Aug 11, 2020 17:05
Abstract The present study analyzed the antitumor effect of γδ T cells transduced with TCR of the cancer‐specific CTL to establish forceful cancer‐specific adoptive immunotherapy. We cloned the TCRαβ genes from the CTL showing HLA B15 restricted recognition of Kita‐Kyushu Lung Cancer antigen‐1 (KK‐LC‐1), a cancer/germline gene antigen, identified in a lung adenocarcinoma case (F1121). The TCRαβ and CD8 genes were transduced into γδ T cells induced from peripheral blood lymphocytes of healthy volunteers...
Tue Aug 11, 2020 17:03
Abstract Purpose Esophageal squamous cell cancer (ESCC) has high rates of recurrence and mortality. Small nucleolar RNA host gene 12 (SNHG12) is known to promote the progression of several cancers. Therefore, we aimed to investigate the expression and role of SNHG12 in ESCC. Methods The expression and clinical value of SNHG12 in esophageal...
Wed Aug 12, 2020 23:19
Abstract Objective To report the incidence of cancer after renal transplantation at a referral center in a developing country. Materials and methods Consecutive patients receiving renal transplantations during a 48-year period at Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran were analyzed. The standardized incidence...
Wed Aug 12, 2020 23:19
Abstract Purpose The aim of this study is to verify if baseline hematological markers, in patients with advanced melanoma receiving BRAF inhibitor (BRAFi)-based therapies, are independently associated with progression free survival (PFS) and overall survival (OS). Methods We retrospectively analyzed 90 patients with metastatic melanoma...
Wed Aug 12, 2020 23:19
Abstract Introduction Urothelial carcinoma (UC) is an aggressive malignancy and has a poor prognosis in the metastatic state. Treatment of UC remains a challenge, and as a first-line regimen for advanced UC, standard platinum-based chemotherapy is unfit for many patients due to numerous comorbidities and poor performance status. Recently, five immune checkpoint inhibitors have been approved for the treatment of patients with advanced...
Wed Aug 12, 2020 23:19
Publication date: September 2020Source: European Journal of Cancer, Volume 137Author(s): Sara M. Federico, Alberto S. Pappo, Natasha Sahr, April Sykes, Olivia Campagne, Clinton F. Stewart, Michael R. Clay, Armita Bahrami, Mary B. McCarville, Sue C. Kaste, Victor M. Santana, Sara Helmig, Jessica Gartrell, Anang Shelat, Rachel C. Brennan, Dana Hawkins, Kimberly Godwin, Michael W. Bishop, Wayne L. Furman, Elizabeth Stewart
Wed Aug 12, 2020 18:01
Publication date: Available online 11 August 2020Source: European Journal of CancerAuthor(s): Michele Montrone, Annamaria Catino, Vincenzo Ostilio Palmieri, Vito Longo, Domenico Galetta
Wed Aug 12, 2020 18:01
Future Oncology, Volume 16, Issue 23, Page 1659-1664, August 2020.
Wed Aug 12, 2020 14:41
Future Oncology, Ahead of Print.
Wed Aug 12, 2020 14:20
Future Oncology, Ahead of Print.
Wed Aug 12, 2020 11:30
Related Articles Immuno-oncology for esophageal cancer. Future Oncol. 2020 Aug 11;: Authors: Yamamoto S, Kato K Abstract Esophageal cancer (EC) is the seventh most common cancer, with a poor prognosis for metastatic EC patients and limited effective drugs for treatment. Nivolumab and pembrolizumab, monoclonal antibodies that inhibit interactions of PD-1 and its ligand (PD-L1), which induce lymphocyte activation, have antitumor activity. The...
Wed Aug 12, 2020 13:30
Abstract We compared clinical performance of p16/Ki‐67 dual‐stained cytology and HPV genotyping, via different algorithms‐alone, or in combination with cytology‐to identify cervical intraepithelial neoplasia grade 2 or worse (CIN2+) and grade 3 or worse (CIN3+) in women referred to colposcopy. We included 492 cervical specimens (134 normal, 130 CIN1, 99 CIN2, 121 CIN3, 8 cancers) randomly selected from 1158 specimens with valid conventional cytology, HPV (cobas 4800 HPV Test) and biopsy results....
Tue Aug 11, 2020 12:31
Abstract Human papillomavirus (HPV) is the well‐established etiologic factor for cervical neoplasia. Cervical conization constitutes an effective treatment for high‐grade cervical intraepithelial neoplasia (HG‐CIN). We conducted an observational study for long‐term outcomes and HPV genotype changes after conization for HG‐CIN. Between 2008 and 2014, patients with newly diagnosed HG‐CIN before conization (Surveillance New [SN] group) and those who had undergone conization without hysterectomy (Surveillance...
Tue Aug 11, 2020 12:30
Breast cancer (BC) is a malignant breast tumor confronted with high invasion, metastasis and recurrence rate, and adipocytes are the largest components in breast tissue. The aberrant adipocytes, especially the...
Wed Aug 12, 2020 03:00
An amendment to this paper has been published and can be accessed via the original article.
Wed Aug 12, 2020 03:00
New approaches are needed to overcome intrinsic therapy resistance in glioblastoma (GBM). Because GBMs exhibit sexual dimorphism and are reported to express steroid hormone receptors, we reasoned that signaling through the androgen receptor (AR) could mediate therapy resistance in GBM, much as it does in AR-positive prostate and breast cancers. We found that nearly half of GBM cell lines, patient-derived xenografts and human tumors expressed AR at the transcript and protein level-with expression...
Wed Aug 12, 2020 16:55
Abstract Introduction The management of skull base malignancies continues to evolve with improvements in surgical technique, advances in radiation delivery and novel systemic agents. Methods In this review, we aim to discuss in detail the management of common skull base pathologies which typically require multimodality therapy, focusing on the radiotherapeutic...
Wed Aug 12, 2020 03:00
Publication date: Available online 12 August 2020Source: Practical Radiation OncologyAuthor(s): Erik S. Blomain, Nataliya Kovalchuk, Elizabeth Neilsen, Lawrie Skinner, Richard T. Hoppe, Susan M. Hiniker
Wed Aug 12, 2020 17:11
Abstract Background Psychosocial costs, or quality of life costs, account for psychological distress, pain, suffering and other negative experiences associated with cancer. They contribute to the overall economic burden of cancer that patients experience. But this category of costs remains poorly understood. This hinders opportunities to make the best cancer control policy decisions. This study explored the psychosocial cost burden associated with cancer, how studies measure psychosocial costs...
Tue Aug 11, 2020 19:52
To develop a low-dose cone beam CT (LD-CBCT) reconstruction method named simultaneous algebraic reconstruction technique and dual-dictionary learning (SART-DDL) joint algorithm for image guided radiation thera...
Wed Aug 12, 2020 03:00
Due to the world-wide introduction of the stepping HDR source based personalized treatment planning and dose-volume optimization procedure in Head and Neck brachytherapy practice, the GEC-ESTRO Head and Neck Working Group published in 2017 an update [2] of the previously (2009) published treatment recommendations [3].
Wed Aug 12, 2020 03:00
Publication date: Available online 11 August 2020Source: Reports of Practical Oncology & RadiotherapyAuthor(s): Tomasz Kolenda, Kacper Guglas, Dawid Baranowski, Joanna Sobocińska, Magda Kopczyńska, Anna Teresiak, Renata Bliźniak, Katarzyna Lamperska
Wed Aug 12, 2020 18:22
Staufen1 (STAU1) is an RNA-binding protein (RBP) that interacts with double-stranded RNA structures and has been implicated in regulating different aspects of mRNA metabolism. Previous studies have indicated that STAU1 interacts extensively with RNA structures in coding regions (CDSs) and 3'-untranslated regions (3'UTRs). In particular, duplex structures formed within 3'UTRs by inverted-repeat Alu elements (IRAlus) interact with STAU1 through its double-stranded RNA-binding domains (dsRBDs). Using...
Wed Aug 12, 2020 19:03
Publication date: October 2020Source: Cancer Epidemiology, Volume 68Author(s): Romain Fantin, Carolina Santamaría Ulloa, Cristina Barboza Solís
Wed Aug 12, 2020 13:38
Publication date: October 2020Source: Cancer Epidemiology, Volume 68Author(s): Olivier Nuñez, Miguel Rodríguez Barranco, Pablo Fernández-Navarro, Daniel Redondo Sanchez, Miguel Ángel Luque Fernández, Marina Pollán Santamaría, María-José Sánchez
Wed Aug 12, 2020 13:38
Publication date: Available online 12 August 2020Source: Surgical Oncology Clinics of North AmericaAuthor(s): Amit Bhatt, Suneel Kamath, Sudish C. Murthy, Siva Raja
Wed Aug 12, 2020 17:02
Publication date: Available online 12 August 2020Source: Surgical Oncology Clinics of North AmericaAuthor(s): Nathan W. Mesko, Alejandro C. Bribriesco, Daniel P. Raymond
Wed Aug 12, 2020 17:02
Publication date: Available online 12 August 2020Source: Surgical Oncology Clinics of North AmericaAuthor(s): Monisha Sudarshan, Sudish C. Murthy
Wed Aug 12, 2020 17:02
Publication date: Available online 12 August 2020Source: Surgical Oncology Clinics of North AmericaAuthor(s): Andrew Tang, Davendra Sohal, Michael McNamara, Sudish C. Murthy, Siva Raja
Wed Aug 12, 2020 17:02
Publication date: Available online 11 August 2020Source: Surgical Oncology Clinics of North AmericaAuthor(s): Usman Ahmad, Sudish C. Murthy
Wed Aug 12, 2020 17:02
Publication date: Available online 11 August 2020Source: Surgical Oncology Clinics of North AmericaAuthor(s): Jesse M.P. Rappaport, James Huang, Usman Ahmad
Wed Aug 12, 2020 17:02
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